Evidence based tools to improve efficiency of currently administered oncotherapies for tumors of the hepatopancreatobiliary system

Table 1 Details of the articles retrieved from the searches

Ref.	Study type	Type of hyperthermia	Tumor type
Falk et al[22], 19861	nRCT	Regional	PC
Kim et al[37], 1989	pOS	Regional	HCC
Kakehi et al[23], 19901	RCT	Regional	Mixed, incl. HCC and PC
Nagata et al[63], 1990	pOS	Regional	Mixed, incl. HCC and CCC
Akuta et al[66], 1991	pOS	Regional	Mixed, incl. HCC
Hamazoe et al[51], 1991	pOS	Regional	Mixed, incl. HCC, PC and BC
Maeda et al[69], 1991	CR	Regional	HCC
Seong et al[65], 1991	CR	Regional	HCC
Yumoto et al[38], 19911	RCT	Regional	HCC
Kim et al[39], 1992	nRCT	Regional	HCC
Tanaka et al[64], 1992	pOS	Regional	Mixed, incl. HCC and CCC
Robins et al[25], 1993	nRCT	Whole-body	Mixed, incl. PC
Maeta et al[67], 1994	rOS	Regional	Mixed, incl. HCC
Seong et al[40], 1994	pOS	Regional	HCC
Nagata et al[41], 1997	pOS	Regional	Mixed, incl. HCC and CCC
Robins et al[26], 1997	nRCT	Whole-body	Mixed, incl. HCC and PC
Dvorák et al[68], 2002	CR	Regional	HCC
Kamisawa et al[74], 2005	pOS	Regional	BC
Ostapenko et al[72], 20051	pOS	Regional	HCC
Mambrini et al[45], 2007	pOS	Regional	BC, incl. CCC and GC
Bull et al[27], 2008	pOS	Whole-body	Mixed, incl. PC
Cho et al[29], 2008	pOS	Regional	Mixed, incl. PC
Ishikawa et al[52], 2008	rOS	Regional	PC
Ohguri et al[31], 20081	rOS	Regional	PC
Zhang et al[30], 2008	pOS	Regional	PC
Bakshandeh-Bath et al[28], 2009	pOS	Whole-body	PC
Maluta et al[53], 20111	pOS	Regional	PC
Dani et al[58], 2012	rOS	mEHT	PC
Ishikawa et al[47], 20121	nRCT	Regional	PC
Tschoep-Lechner et al[33], 2013	rOS	Regional	PC
Wang et al[73], 2013	pOS	Regional	HCC
Gadaleta-Caldarola et al[42], 2014	pOS	mEHT	HCC
Volovat et al[32], 2014	pOS	Regional	PC
Chen et al[46], 2016	rOS	Regional	CCC
Dong et al[20], 20161	RCT	Regional	HCC
Yu et al[43,44], 2016, 20171	nRCT	Regional	HCC
Datta et al[62], 2017	RCT	Regional	PC
Fan et al[34], 2017	rOS	Regional	PC
Maebayashi et al[54], 2017	rOS	Regional	PC
Pang et al[59], 2017	RCT	mEHT	Mixed, incl. HCC and PC
Bonucci et al[57], 2018	CR	Regional	PC
Ryu et al[75], 2018	CR	Regional	CCC
Werthmann et al[56], 2018	CR	Regional	PC
Fiorentini et al[36], 2019	rOS	mEHT	PC
He et al[35], 2019	rOS	Regional	PC
Iyikesici et al[55], 2020	rOS	Regional	PC

Most subjects included in the studies were patients with advanced or metastatic malignancies with no probability of cure with conventional treatments (Stage III and IV).

¹Study including some Stage I and II patients. BC: Biliary cancer; CCC: Cholangiocellular cancer; CR: Case report; GC: Gallbladder cancer; HCC: Hepatocellular cancer; mEHT: Modulated electrohyperthermia; nRCT: Non-randomized clinical trial; PC: Pancreatic cancer; pOS: Prospective observational study; RCT: Randomized clinical trial; rOS: Retrospective observational study.