Expression profiles of gastric cancer molecular subtypes in remnant tumors

Table 1 Clinical and pathological characteristics of primary gastric cancer and remnant gastric cancer patients

	Primary GC	Remnant GC
Variables	n 284 (%)	n 40 (%)	P value
Sex			< 0.001a
Female	118 (41.5)	5 (12.5)
Male	166 (58.5)	35 (87.5)
Age (yr)			< 0.001a
mean (SD)	61.6 (12)	69.0 (7.7)
BMI (kg/cm²)			0.010a
mean (SD)	24.4 (5.4)	22.0 (4.1)
Albumin (g/dL)			0.241
mean (SD)	4.2 (2.0)	3.8 (0.6)
Hemoglobin (g/dL)			< 0.001a
mean (SD)	12.3 (2.2)	10.6 (2.1)
Neutrophil lymphocyte ratio			0.600
mean (SD)	2.56 (2.25)	2.75 (1.20)
Charlson-Deyo Comorbidity Index			0.956
0-1	200 (70.4)	28 (70)
> 1	84 (29.6)	12 (30)
ASA classification			0.136
I/II	251 (88.4)	32 (80)
III/IV	33 (11.6)	8 (20)
Tumor size (cm)			0.206
mean (SD)	4.87 (3.14)	5.6 (3.3)
Lauren’s type			0.764
Intestinal	149 (52.5)	22 (55)
Diffuse/mixed	135 (47.5)	18 (45)
Grade of histological differentiation			0.709
Well/moderately differentiated	126 (44.4)	19 (47.5)
Poorly differentiated	158 (55.6)	21 (52.5)
Lymphatic invasion			0.900
No	138 (48.9)	20 (50)
Yes	144 (51.1)	20 (50)
Venous invasion			0.292
No	188 (66.7)	30 (75)
Yes	94 (33.3)	10 (25)
Perineural invasion			0.642
No	144 (51.4)	19 (47.5)
Yes	136 (48.6)	21 (52.5)
Number of lymph nodes			< 0.001a
mean (SD)	41.9 (17.8)	23.4 (13.5)
pT			0.590
T1/T2	112 (39.4)	14 (35)
T3/T4	172 (60.6)	26 (65)
pN			0.617
N0	123 (43.3)	19 (47.5)
N+	161 (56.7)	21 (52.5)
pTNM			0.518
I/II	155 (54.6)	24 (60)
III/IV	129 (45.4)	16 (40)

^aP values are statistically significant. ASA: American Society of Anesthesiologists; BMI: Body mass index; GC: Gastric cancer; SD: Standard deviation; TNM: Tumor-node-metastasis.

Table 2 Expression profiles of primary gastric cancer and remnant gastric cancer patients

	Primary GC	Remnant GC
Variables	n 284 (%)	n 40 (%)	P value
EBV			0.039a
Negative	254 (89.4)	31 (77.5)
Positive	30 (10.6)	9 (22.5)
MSI/MSS status			0.362
MSS	224 (78.9)	29 (72.5)
MSI	60 (21.1)	11 (27.5)
p53			0.121
Normal	177 (62.8)	20 (50)
Aberrant	105 (37.2)	20 (50)
E-cadherin			0.565
Normal	255 90.7)	35 (87.5)
Loss of expression	26 (9.3)	5 (12.5)
Profiles with altered expression (EBV, MSI, E-cadherin, p53)			< 0.001a
One or none	261 (91.9)	26 (65)
Two or more	23 (8.1)	14 (35)
Number of altered profiles			-
0	86 (30.3)	13 (32.5)
1	175 (61.6)	13 (32.5)
2	23 (8.1)	11 (27.5)
3	0 (0)	2 (5)
4	0 (0)	1 (2.5)

^aP values are statistically significant. EBV: Epstein-Barr virus; GC: Gastric cancer; MSI: Microsatellite instability; MSS: Microsatellite stable.