Latest therapeutic target for gastric cancer: Anthrax toxin receptor 1

Table 1 Biological function of anthrax toxin receptor 1

Biological function of ANTXR1	Summary of findings	Ref.
Non-tumor related biological function	Regulates extracellular matrix homeostasis	Sergeeva et al[6] and Hu et al[7]
	Regulates angiogenesis	Sergeeva et al[6] and Besschetnova et al[8]
	Regulates cell migration, and skin elasticity.	Sergeeva et al[6]
	Regulates the proliferation and apoptosis of chondrocytes	Jiang et al[9]
Tumor related biological function	Regulates tumor growth and Metastasis	Høye et al[10] and Evans et al[12]
	Overexpress in gastric adenocarcinoma	Sotoudeh et al[11]
	Active the PI3K/AKT/mTOR signaling pathway	Cai et al[19]
	Mediates uPA-stimulated EGFR phosphorylation	Zhang et al[13]
	Promotes tumor angiogenesis	Nanda et al[16] and Chaudhary et al[17]

uPA: Urokinase plasminogen activator.

Table 2 Role of anthrax toxin receptor 1 in different kinds of cancer

Different kinds of cancer	Summary of findings	Ref.
Gastric cancer	Overexpress in gastric adenocarcinoma	Sotoudeh et al[11]
	Active the PI3K/AKT/mTOR signaling pathway	Cai et al[19]
	It is the potent antigenic targets for CAR T cell therapy	Sotoudeh et al[18]
Colorectal cancer	Influence tumor development by disrupting tumor vasculature.	Fernando et al[20]
	It possible use as biomarkers for screening, diagnosis, and therapy	Pietrzyk et al[21]
Lung cancer	It regulates the proliferation, apoptosis, migration and invasion of lung cancer cells.	Gong et al[22]
	It is an excellent indicator for early clinical diagnosis and prognosis of lung cancer.	Sun et al[23]
Breast cancer	It enhances tumor immunity in conjunction with immunization against differentiation ag.	Felicetti et al[24]
	It expression in triple-negative breast cancer.	Gutwein et al[25]
	It enhances tumor growth and metastasis in breast cancer cells.	Opoku-Darko et al[26]
	ANTXR1-Specific CAR T cells as a targeted therapy for breast cancer.	Byrd et al[27]