Identification of a nine-gene prognostic signature for gastric carcinoma using integrated bioinformatics analyses

Table 1 Nine prognosis-associated genes for establishing the risk score system

Gene symbol	Description	Coef	HR	95%CI	P value
COL8A1	Collagen type VIII alpha 1 chain	-0.39134	0.6761	0.4974-0.9191	0.01247a
CTHRC1	Collagen triple helix repeat containing 1	0.36470	1.4401	1.1432-1.8140	0.00196a
COL5A2	Collagen type V alpha 2 chain	0.45550	1.5770	0.9116-2.7278	0.10329
AADAC	Arylacetamide deacetylase	0.14823	1.1598	1.0437-1.2887	0.00585a
MAMDC2	MAM domain containing 2	0.21034	1.2341	1.0514-1.4485	0.01006a
SERPINE1	Serpin family E member 1	0.23183	1.2609	1.0583-1.5023	0.00949a
MAOA	Monoamine oxidase A	0.17086	1.1863	1.0151-1.3865	0.03172a
COL1A2	Collagen type I alpha 2 chain	-0.54104	0.5821	0.3462-0.9790	0.04135a
FNDC1	Fibronectin type III domain containing 1	0.23264	1.2619	0.9808-1.6236	0.07041

^aP < 0.05 was considered statistically significant. HR: Hazard ratio.

Table 2 Results of connectivity map analysis

Rank	CMap name	mean	n	Enrichment	P value	Specificity	Percent non-null
1	Trichostatin A	-0.344	182	-0.364	< 0.001	0.5545	50
2	Thiamphenicol	-0.469	5	-0.78	0.001	0.0333	60
3	Vorinostat	0.419	12	0.518	0.002	0.4221	66
4	Levomepromazine	-0.245	4	-0.814	0.002	0.0094	50
5	Lasalocid	-0.299	4	-0.789	0.004	0.0463	50
6	Clorsulon	-0.303	4	-0.76	0.007	0.0284	50
7	Prestwick-1103	-0.299	4	-0.759	0.007	0.0397	50
8	Aminobenzenesulfonamide	-0.389	4	-0.712	0.014	0.0486	50
9	Digoxigenin	-0.393	5	-0.625	0.019	0.1071	60
10	Disulfiram	-0.404	5	-0.616	0.023	0.0935	60

CMap: Connectivity map.