Subtotal gastrectomy combined with chemotherapy: An effective therapy for patients with circumscribed Borrmann type IV gastric cancer

Table 1 Main clinicopathological characteristics of patients with circumscribed Borrmann type IV gastric cancer

Variable	B-4 patients (n = 117)
Age (yr)	57.55 ± 10.69
Gender
Male	75
Female	42
Diameter (cm)	7.81 ± 3.07
Tumor location
Upper 1/3–1/2 (U or MU)	22
Lower 1/3–1/2 (M or L or ML)	59
Total (LAU or LMU)	36
Radical degree
R0	45
R1+	72
Histological type
Well	8
Poor	109
pT stage
pT3	36
pT4	81
pN stage
pN0	22
pN1	15
pN2	15
pN3	65
Venous/lymphatic infiltration
Yes	74
No	43
Gastrectomy type
Subtotal gastrectomy	26
Total gastrectomy	91
Adjuvant chemotherapy
Yes	74
No	43

U: Upper; M: Middle; L: Lower; pT: Tumor invasion depth; pN: Lymph node status.

Table 2 Cox univariate and multivariate analyses of circumscribed Borrmann type IV patients

Variable	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age (yr)	1.012 (0.992-1.033)	0.226
Gender	0.969 (0.638-1.470)	0.881
Diameter (cm)	1.086 (1.013-1.164)	0.02
Tumor location	1.206 (0.879-1.655)	0.246
Radical degree	1.575 (0.687-3.612)	0.283
Histological type	0.708 (0.310-1.620)	0.414
pT stage	1.422 (1.021-1.982)	0.037
pN stage	1.482 (1.224-1.794)	0.000	1.433 (1.179-1.742)	0.000
Venous/lymphatic infiltration	0.934 (0.615-1.418)	0.748
Gastrectomy type	0.330 (0.182-0.595)	0.000	0.400 (0.219-0.728)	0.003
Postoperative chemotherapy	0.482 (0.320-0.727)	0.001	0.564 (0.373-0.853)	0.007

HR: Hazard ratio; CI: Confidence interval; pT: Tumor invasion depth; pN: Lymph node status.

Table 3 Factors associated with postoperative peritoneal cavity metastasis in Borrmann type IV patients

Variable	PPCM (79)	Non-PPCM (22)	Pearson P value
Tumor location			0.497
Upper 1/3–1/2 (U or MU)	13	4
Lower 1/3–1/2 (M or L or ML)	41	13
Total (LAU or LMU)	25	5
Radical degree			0.107
R0	28	12
R1+	51	10
Gastrectomy type			0.112
Subtotal gastrectomy	13	7
Total gastrectomy	66	15
Venous/lymphatic infiltration			0.416
Yes	50	16
No	29	6
pT stage			0.559
pT3	23	5
pT4	56	17
pN stage			0.005b
pN0	9	8
pN1-3	70	14
Chemotherapy			0.105
Yes	46	17
No	33	5

^bP < 0.01. PPCM: Postoperative peritoneal cavity metastasis; U: Upper; M: Middle; L: Lower; pT: Tumor invasion depth; pN: Lymph node status.

Table 4 Role of chemotherapy in suppressing postoperative peritoneal cavity metastasis in patients who underwent different gastrectomy procedures

	Subtotal gastrectomy (20)			Total gastrectomy (81)
	PPCM (13)	Non-PPCM (7)	Pearson P value	PPCM (66)	Non-PPCM (15)	Pearson P value
Chemotherapy	4	6	0.018a	45	8	0.281
Non-chemotherapy	9	1		21	7

^aP < 0.05. PPCM: Postoperative peritoneal cavity metastasis.