Iodine-125 implantation with transjugular intrahepatic portosystemic shunt for main portal vein tumor thrombus

Table 1 Baseline characteristics on patients

	TIPS-125I group(n = 40)	TIPS only group(n = 45)	P-value
Gender			0.961
Male	27	30
Female	13	15
Average age	51 ± 4.3	49 ± 6.9	0.311
Etiology			0.923
Hepatitis B or C	24	28
Alcoholic	8	7
Cholestasis	4	6
Other	4	4
Child-Push classification			0.384
A	6	10
B	20	16
C	14	19
Albumin (g/L)	30 ± 11	32 ± 11	0.915
Direct bilirubin (umol/L)	23.1 ± 16.9	21 ± 15	0.43
Alanine aminotransferase (U/L)	49 ± 36	53 ± 41	0.756
Aspartate aminotransferase (U/L)	42.5 ± 26.5	50.5 ± 37.5	0.318
Na+	135.5 ± 15.5	138.5 ± 16.5	0.384
K+	3.73 ± 1.27	3.49 ± 1.31	0.609
MELD score	11.96 ± 1.68	12.77 ± 2.49	0.187
Clinical symptoms			0.486
Hemorrhage	29	32
Chest and/or abdominal dropsy	6	5
Both	5	8
First-grade branch of portal vein			0.571
Unobstructed	18	22
Obstructed	22	23

TIPS: Transjugular intrahepatic portosystemic shunt; MELD score: Model for end-stage liver disease score.

Table 2 The portosystemic pressure gradient before and after transjugular intrahepatic portosystemic shunt was significantly different in the two groups

	PPG before TIPS (mmHg)	PPG after TIPS (mmHg)	Number	t	df	P-value	SD of difference	SEM of difference	R squared
TIPS-125I group	26.96 ± 5.73	13.1 ± 5.9	40	20.88	39	< 0.0001	4.367	0.6905	0.9179
TIPS only group	26.12 ± 5	12.6 ± 5.4	45	22.94	44	0.0002	4.089	0.6096	0.9228

TIPS: Transjugular intrahepatic portosystemic shunt; PPG: Portosystemic pressure gradient.

Table 3 The rates of symptom recurrence, stent restenosis and survival during follow-up

	TIPS-125I group	TIPS only group	P-value
Rate of stent stenosis			< 0.05
6 mo	12.5	42.2
12 mo	27.5	68.9
24 mo	42.5	84.4
Rate of symptom recurrence			< 0.05
6 mo	7.5	31.1
12 mo	22.5	62.2
24 mo	35	82.2
Survival rate			< 0.05
6 mo	80	64.4
12 mo	45	24.4
24 mo	20	4.4

TIPS: Transjugular intrahepatic portosystemic shunt.

Table 4 The multivariate analysis of survival

	Univariate analysis			Multivariate analysis
	HR	95%CI	P-value	HR	95%CI	P-value
Group	1.943	1.219-3.097	0.005	2.631	1.603-4.318	< 0.001
MELD score	1.042	0.849-1.279	0.692	1.697	1.261-2.282	< 0.001
DBIL	0.988	0.965-1.012	0.338			0.161
ALT	0.991	0.979-1.003	0.150			0.078
Child-Pugh classification			< 0.001			< 0.001
B/A	1.546	0.793-3.016	0.201	3.783	1.718-8.329
C/A	3.493	1.764-6.918	< 0.001	13.87	5.192-37.07

MELD score: Model for end-stage liver disease score; DBIL: Direct bilirubin; ALT: Alanine aminotransferase.