Identification of genomic features associated with immunotherapy response in gastrointestinal cancers

Table 1 Six immune signatures and their associated gene sets

Immune signature	Gene set
B cells	BACH2, BANK1, BLK, BTLA, CD79A, CD79B, FCRL1, FCRL3, HVCN1, RALGPS2
CD8+ T cells	CD8A
Cytolytic activity	PRF1, GZMA
HLA	HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DPB2, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB5, HLA-DRB6, HLA-E, HLA-F, HLA-G, HLA-J
IFN	DDX4, IFIT1, IFIT2, IFIT3, IRF7, ISG20, MX1, MX2, RSAD2, TNFSF10, GPR146, SELP, AHR
NK	KLRC1, KLRF1

HLA: Human leukocyte antigen; IFN: Interferon; NK: Natural killer.