Improved method for inducing chronic atrophic gastritis in mice

doi:10.4251/wjgo.v11.i12.1115

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Dec 15, 2019 (publication date) through Nov 6, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Dec 15, 2019; 11(12): 1115-1125
Published online Dec 15, 2019. doi: 10.4251/wjgo.v11.i12.1115

Table 1 Identification of cultures isolated from gastric mucosa of mice in the combined group based on biochemical indices

Group	Oxidase	Peroxidase	Urease
Positive control	+	+	+
Negative control	-	-	-
Isolated culture	+	+	+

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Table 2 Immunological functionsof mice in the combined group

Group	CD4+			CD8+
Group	30^th d	90^th d	120^th d	30^th d	90^th d	120^th d
PBS control	52.56 ± 1.82	51.27 ± 2.05	52.84 ± 1.49	28.13 ± 1.92	29.41 ± 2.39	30.07 ± 1.24
Combined	40.17 ± 1.36	44.38 ± 2.11	43.97 ± 2.08	22.08 ± 1.42	25.53 ± 1.87	25.19 ± 1.53

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Table 3 Modelling results of chronic atrophic gastritis

Group	The number of mice developing CAG		The number of mice with Hp colonisation		Success rate
Group	90^th d after infection	120^th d after infection	90^th d after infection	120^th d after infection	Success rate
PBS control	0	0	0	0	0
Hp	0	0	90% (9/10)	100% (10/10)	0
MNNG	0	0	0	0	0
Ammonia water	0	0	0	0	0
Combined	90% (9/10)	90 (9/10)	100% (10/10)	100% (10/10)	90%

CAG: chronic atrophic gastritis; MNNG: N-methyl-N'-nitroguanidine.

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Citation: Wei X, Feng XP, Wang LY, Huang YQ, Liang LL, Mo XQ, Wei HY. Improved method for inducing chronic atrophic gastritis in mice. World J Gastrointest Oncol 2019; 11(12): 1115-1125
URL: https://www.wjgnet.com/1948-5204/full/v11/i12/1115.htm
DOI: https://dx.doi.org/10.4251/wjgo.v11.i12.1115