Comparison between laparoscopic and open surgery for large gastrointestinal stromal tumors: A meta-analysis

Table 1 Main characteristics of enrolled trials

Ref.	Region	Year	Study design	Study period	Sample size		Tumor size (cm)		CS	Follow-up (mo)
					LAP	Open	LAP	Open
Kim et al[10]	South Korea	2012	OCS (R)	1998-2011	24	14	6.1 ± 1.3	7.2 ± 1.7	0	49.3 (8.4-164.4)
Lin et al[11]	China	2014	OCS (R)	2007-2012	23	23	7.2 ± 1.6	7.3 ± 1.5	1	34.0 (6-78)
Hsiao et al[12]	Taiwan	2015	OCS (P)	2002-2012	18	37	6.1 ± 1.0	6.0 ± 0.9	0	43.2 (16.8-133.2)
Takahashi et al[13]	Japan	2015	OCS (R)	1995-2011	12	15	7.5 ± 1.9	5.5 ± 0.73	3	63 (7-154)
Khoo et al[14]	Japan	2016	OCS (R)	2002-2015	23	36	NA	NA	1	45

OCS: Observational clinical study; R: Retrospective study; P: Prospective study; NA: Not available; CS: Convention surgery.

Table 2 Newcastle-Ottawa Scale Assessment of enrolled studies

Ref.	Selection (0-4)				Comparability		Outcome (0-3)			Total
	REC	Snec	AE	OINP	SCB	SCA	AO	FU	AFC
Kim et al[10]	1	1	1	1	1	0	1	1	1	8
Lin et al[11]	1	1	1	1	1	1	1	1	0	8
Hsiao et al[12]	1	1	1	1	1	0	1	1	1	8
Takahashi et al[13]	1	1	1	0	1	0	1	1	1	7
Khoo et al[14]	1	1	1	1	1	1	1	1	1	9

REC: Representativeness of the exposed cohort; SNEC: Selection of the no exposed cohort; AE: Ascertainment of exposure; OINP: Outcome of interest not presented in the start of study; SCB: Study controls for basic characteristics; SCA: Study controls for additional factor; AO: Assessment of outcome; FU: Follow-up; AFC: Adequacy of follow up.

Table 3 Summary results of meta-analysis of clinical outcomes

Outcomes	No. of studies	Effect value	95%CI of effect	Heterogeneity
				I2 (%)	P value
Tumor size	4	WMD = -0.0.38	-0.699 to 0.362	53.3	0.073
Operation time	5	WMD = 7.17 min	-56.02 to 70.36	92.9	0.000
Blood loss	4	WMD = -47.47 mL	-93.20 to -1.73	63.2	0.043
Postoperative complications	5	OR = 0.93	0.34 to 2.50	0.0	0.858
Postoperative stay	5	WMD = -2.81 d	-3.68 to -1.94	38.7	0.163
Progression-free survival	5	HR = 0.64	0.35 to 1.19	0.0	0.553

WMD: Weighted mean differences.