Clinical Practice Study
Copyright ©The Author(s) 2018.
World J Gastrointest Oncol. Jan 15, 2018; 10(1): 40-47
Published online Jan 15, 2018. doi: 10.4251/wjgo.v10.i1.40
Table 1 Patient characteristics
Characteristicn = 30
Sex, M/F19/11
Age, median (range)53 (30-70)
Tumor location, distance from anal verge
≤ 5 cm19 (63)
> 5 cm11 (37)
Clinical TN stage
T2N21 (3)
T3N02 (7)
T3N115 (50)
T3N212 (40)
Tumor differentiation
Well10 (33)
Moderate10 (33)
Poor4 (14)
Mucinous3 (10)
Signet ring cell3 (10)
Table 2 Clinical (cT2) and pathological (ypT) tumor stages
cT2cT3Total
ypT0-6 (20.6)6 (20.6)
ypT1-3 (10.3)3 (10.3)
ypT2-8 (27.5)6 (20.6)
ypT3111 (37.9)12 (41.3)
Total12829
Table 3 Surgical complications
Timing of the complication
Perioperative6 (20.6)1
Early postoperative4 (13.7)2
Late postoperative2 (6.8)3
Table 4 Studies investigating hyperfractionated accelerated radiotherapy regimen for locally advanced rectal cancer
StudyNumber of patientsDesignFollow-up (mo)Total RT doseIntervals (wk)Concomitant chemotherapypCR1Local controlDown-staging
Coucke et al[24] 2006250Prospective39 mo41.6 Gy/1.6 Gy1 wkNone1.20%91.70%38%
Ceelen et al[22] 200750 vs 91Prospective67 mo vs 28 mo41.6 Gy/1.6 Gy vs 45 Gy/1.8 Gy13 d vs 6 wkNone vs 5-FU bolus chemotherapy4% vs 18%94% vs 95.6%30% vs 51%
Voelter et al[23] 200633Prospective104 mo41.6 Gy/1.6 Gy1wkCPT-11NA100%33%
Brooks et al[42] 200620Prospective31 mo25 Gy/1.67 Gy (CHART)1 wkNoneNA95%NA
Widder et al[43] 2005184Prospective43 mo25 Gy/2.5 Gy1 wkNoneNA97.90%NA
Bouzourene et al[29] 2003104Prospective40 mo41.6 Gy/1.6 Gy1 wkNone0%92.30%43%
Marsh et al[26] 201017ProspectiveNA50.4-55.2 Gy/1.2 Gy4-6 wkCapesitabine 825 mg/m2-twice per day18.80%NA81.25%
The present study30Prospective60 mo42 Gy/1.5 Gy6-8 wk5-FU (325 mg/m2) continuous infusion21%96.70%59%
Table 5 Biological equivalent doses[44]
Tumor control/acute normal tissue complication probability
Late normal tissue complication probability
Bed (Gy) (α/β = 10 Gy)Bed (Gy) (α/β = 3 Gy)
RegimenNo time correctionWith time correction
25 Gy/5 fr/5 d (d = 5 Gy)37.537.566.7
50 Gy/25 fr/33 d (d = 2 Gy)60.044.483.4
42 Gy/28 fr/18 d (d = 1.5 Gy)48.341.763.0