Review
Copyright ©The Author(s) 2018.
World J Gastrointest Oncol. Jan 15, 2018; 10(1): 15-22
Published online Jan 15, 2018. doi: 10.4251/wjgo.v10.i1.15
Table 1 Sensitivity and specificity of the SEPT9 gene methylation assay for colorectal cancer detection
PublicationsNumber of casesSensitivitySpecificityAlgorithmAssay usedRef.
Tóth et al (2012)184 (92 CRC, 92 no evidence of disease)95.6%84.8%1/3Epi proColon 2.0[27]
(95%CI: 89.2%-98.8%)(95%CI: 75.8%-91.4%)
79.3%98.9%2/3
(95%CI: 69.6%-87.1%)(95%CI: 94.1%-100%)
Church et al (2014)1516 (53 CRC, 1457 without CRC)48.2%91.5%1/3Epi proColon 1.0[31]
(95%CI: 32.%-63.6%)(95%CI: 89.7%-93.1%)
Potter et al (2014)1544 (44 CRC, 1500 non-CRC)68.0%80.0%-Epi proColon 1.0[34]
(95%CI: 53%-80%)(95%CI: 78%-82%)
Su et al (2014)234 (172 CRC, 62 controls)88.4%93.5%-MSP-DHPLC[28]
Johnson et al (2014)301 (101 CRC, 200 non-CRC)73.3%81.5%-Epi proColon 1.0[32]
(95%CI: 63.9%-80.9%)(95%CI: 75.5%-86.3%)
Jin et al (2014)476 (135 CRC, 341 non-CRC)74.8%87.4%2/3Epi proColon 2.0[29]
(95%CI: 67.0%-81.6%)(95%CI: 83.5%-90.6%)
Ørntoft et al (2015)300 (150 CRC, 150 controls)73.0%82.0%1/3Epi proColon 1.0[33]
(95%CI: 64%-80%)(95%CI: 75%-88%)
Sharif et al (2016)90 (45 CRC, 45 controls)84.4%99.0%-MS-HRM assay[52]
Wu et al (2016)1031 (291 CRC, 740 non-CRC)73.0%97.5%-Epi proColon 2.0[30]
76.6%95.9%-New SEPT9 assay
(95%CI: 71.3%-81.4%)
Nian et al (2016)25 studies, 9927 samples (2975 (CRC, 6952 non-CRC)71.0%92.0%2/3Epi proColon 2.0[35]
(95%CI: 67%-75%)(95%CI: 89%-94%)
CRC: Colorectal cancer.