Copyright
©The Author(s) 2018.
World J Gastrointest Oncol. Jan 15, 2018; 10(1): 1-14
Published online Jan 15, 2018. doi: 10.4251/wjgo.v10.i1.1
Published online Jan 15, 2018. doi: 10.4251/wjgo.v10.i1.1
Tissue (epithelium) | Monoallelic MSH3 germline mutation | Bi-allelic MSH3 germline mutation |
Normal colonic mucosa | MSH3 expressed | MSH3 absent |
Colon adenoma | Not obtained | MSH3 absent |
MLH1 promoter hypermethylation | 22/35 (63%) of hypermutated CRCs | 8/22 (36%) with MSH3 frameshift mutation |
1/22 (4.5%) with MSH3 missense/nonsense mutation | ||
0/22 (0%) with MSH2 mutation | ||
5/22 (23%) with MSH6 frameshift mutation | ||
4/22 (18%) with MSH6 missense/nonsense mutation | ||
POLE mutation | 13/35 (37%) of hypermutated CRCs | 3/13 (23%) with MSH3 frameshift mutation |
2/13 (15%) with MSH3 missense/nonsense mutation | ||
5/13 (38%) with MSH2 missense/nonsense mutation | ||
0/13 (0%) with MSH6 frameshift mutation | ||
7/13 (54%) with MSH6 missense/nonsense mutation |
- Citation: Koi M, Tseng-Rogenski SS, Carethers JM. Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer. World J Gastrointest Oncol 2018; 10(1): 1-14
- URL: https://www.wjgnet.com/1948-5204/full/v10/i1/1.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v10.i1.1