Review
Copyright ©The Author(s) 2018.
World J Gastrointest Oncol. Jan 15, 2018; 10(1): 1-14
Published online Jan 15, 2018. doi: 10.4251/wjgo.v10.i1.1
Table 1 Expression of MSH3 protein within the epithelium of normal colonic mucosa and adenoma of patients with mono- or bi-allelic germline mutation in MSH3
Tissue (epithelium)Monoallelic MSH3 germline mutationBi-allelic MSH3 germline mutation
Normal colonic mucosaMSH3 expressedMSH3 absent
Colon adenomaNot obtainedMSH3 absent
Table 2 Comparison of type of mismatch repair gene mutations between sporadic hypermethylated MLH1 colorectal cancers and POLE mutation colorectal cancers from TCGA
MLH1 promoter hypermethylation22/35 (63%) of hypermutated CRCs8/22 (36%) with MSH3 frameshift mutation
1/22 (4.5%) with MSH3 missense/nonsense mutation
0/22 (0%) with MSH2 mutation
5/22 (23%) with MSH6 frameshift mutation
4/22 (18%) with MSH6 missense/nonsense mutation
POLE mutation13/35 (37%) of hypermutated CRCs3/13 (23%) with MSH3 frameshift mutation
2/13 (15%) with MSH3 missense/nonsense mutation
5/13 (38%) with MSH2 missense/nonsense mutation
0/13 (0%) with MSH6 frameshift mutation
7/13 (54%) with MSH6 missense/nonsense mutation