Multimodality treatment strategies have changed prognosis of peritoneal metastases

Figure 1 Kaplan-Meier survival curve of non-gynecological peritoneal carcinomatosis, stratified according to the Gilly staging system (Stage 0, 1 and 2 vs Stage 3 and 4)[2] (with permission). Kaplan-Meier survival curve according to PM staging[2]: Available from: URL: http://click.info.copyright.com/?qs=e232cb87f594dcec17211f4d00b2929249713825e6b912c104538a1695c335dde91d3fdf5f03fa97. PM: Peritoneal metastases.

Figure 2 Kaplan-Meier survival curve of metastatic colorectal cancer stratified according to the metastatic locations (peritoneal carcinomatosis vs non peritoneal carcinomatosis) and chemotherapy protocols (fluorouracil, leucovorin and oxaliplatin; fluorouracil, leucovorin and irinotecan; irinotecan and oxaliplatin)[7] (with permission). Kaplan-Meier survival curve of Metastatic Colorectal Cancer stratified by peritoneal metastatic status and chemotherapy protocols[7]: Available from: URL: http://click.info.copyright.com/?qs=da4305023350a474912bb7bdbc04210a63a294c209e715b6497fdff613ea3697d486bdb9bffe0470. pcCRC: Peritoneal carcinomatosis from colorectal cancer.

Figure 3 Kaplan-meier survival curve of colorectal peritoneal carcinomatosis stratified by chemotherapy protocols[8] (with permission). Kaplan-Meier survival curve of Colorectal PM stratified by chemotherapy protocols[8]: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (Available from: URL: http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PM: Peritoneal metastases. 5FU: 5-fluorouracil.

Figure 4 Kaplan-Meier survival curve comparing hyperthermic intraperitoneal chemotherapy to standard treatment, for colorectal peritoneal carcinomatosis[35] (with permission) (A) and comparing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy treatment to systemic chemotherapy alone, for colorectal peritoneal carcinomatosis[45] (with permission) (B). A: Kaplan-Meier survival curve comparing HIPEC to standard treatment, for Colorectal PM[35]: Available from: URL: http://click.info.copyright.com/?qs=2b7046b10dd0c5471bbbb8bac0096e00e895f442c0326423c4ec2ccdd7b4701b99fd4bd5b32f0283; B: Kaplan-Meier survival curves comparing CRS-HIPEC treatment to systemic chemotherapy alone, for Colorectal PM[45]: Available from: URL: http://click.info.copyright.com/?qs=2b7046b10dd0c5471bbbb8bac0096e00e895f442c03264235cab52a23497a2d7e22ca0949c16bf1f. CRS-HIPEC: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy; PM: Peritoneal metastases.

Figure 5 Kaplan-Meier survival curves comparing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy treatment to cytoreductive surgery alone, for gastric peritoneal carcinomatosis[47] (with permission). Kaplan-Meier survival curves comparing CRS-HIPEC treatment to CRS alone, for Gastric PM[47]: This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. CRS-HIPEC: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy; PM: Peritoneal metastases.

Figure 6 Overall survival compared with disease-free survival for pseudomyxoma peritonei (A) and colorectal peritoneal carcinomatosis (B), treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, from the Netherlands[52] (with permission). Overall and disease-free survival of Pseudomyxoma Peritonei (A) and Colorectal PM (B), treated with CRS-HIPEC, from the Netherlands[52]: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CRS-HIPEC: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy; PM: Peritoneal metastases.

Figure 7 Kaplan-Meier survival curve of colorectal peritoneal carcinomatosis treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, stratified according to the size of residual tumors (A) and the number of regions with residual tumors (B)[35] (with permission). Kaplan-Meier survival curve of CRS-HIPEC treatment, for Colorectal PM, stratified by the number of regions affected (A) and the number of regions with residual tumors (B)[35]: http://click.info.copyright.com/?qs=2b7046b10dd0c5471bbbb8bac0096e00e895f442c0326423c4ec2ccdd7b4701b99fd4bd5b32f0283. CRS-HIPEC: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy; PM: Peritoneal metastases.

Figure 8 Kaplan-Meier survival curve of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy treatment, for colorectal peritoneal carcinomatosis, stratified by completeness of cytoreduction score[33] (with permission). Kaplan-Meier survival curve of CRS-HIPEC treatment, for Colorectal PM, stratified by CCRS[33]: Available from: URL: http://click.info.copyright.com/?qs=2b7046b10dd0c5471bbbb8bac0096e00e895f442c0326423b795894c1892230b84270e7e00c4e014. CCRS: Completeness of cytoreduction score; CRS-HIPEC: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy; PM: Peritoneal metastases.

Figure 9 Kaplan-Meier survival curve of colorectal peritoneal carcinomatosis stratified according to hepatic involvement (peritoneal carcinomatosis alone vs peritoneal carcinomatosis with hepatic metastases)[86] (with permission). Kaplan-Meier survival curve of Colorectal PM alone and PM with Hepatic Metastases[86]: Available from: URL: http://click.info.copyright.com/?qs=2b7046b10dd0c5471bbbb8bac0096e00e895f442c032642364879a25688a50cc82757e6f8509f6e1. PM: Peritoneal metastases.

Figure 10 Kaplan-Meier survival curve for colorectal peritoneal metastases and colorectal hepatic metastases, who achieved optimal treatment[102] (with permission). Kaplan-Meier survival curve for Colorectal PM and Colorectal Hepatic Metastases, with optimal treatment[102]: Available from: URL: http://click.info.copyright.com/?qs=751ae7c8f8e03ecb0a4741c79a3b341599b5318899e258b3d458148f31158885e37d98de5cb03229. PM: Peritoneal metastases.