Monoclonal antibodies that target the immunogenic proteins expressed in colorectal cancer

Figure 1 Correlating the extent of local tumor progression with survival in colorectal cancer.

Figure 2 Depicts the ideal monoclonal antibody that can define the presence of a tumor associated antigen for diagnosis by Immunohistochemistry and then when delivered IV, can hunt and destroy the tumor which contains the diagnostic marker. IHC: Immunohistochemistry; TAA: Tumor associated antigen; ELISA: Enzyme-linked immunosorbent assay.

Figure 3 Reveals expression of tumor antigen in those colonocytes adjacent to the malignant lesion where the colonocytes appear normal by H and E.

Figure 4 Animal models (nude mice) growing human malignancy to compare untreated and treated animals. The upper model received a control mAb while the lower animal model having had a much smaller tumor mass at 10 d received mAb NPC-1.