Epigenetic field defects in progression to cancer

Figure 1 Roles of DNA damage, reduced DNA repair and epigenetic alterations in a field defect in progression to cancer.

Figure 2 Schematic of a field defect in progression to cancer.

Figure 3 Human colon resection about 17 cm long, opened longitudinally to show inner epithelium, with cancer in center of inner surface.

Figure 4 Reduced expression of DNA repair proteins ERCC1 and PMS2 and lack of reduction of DNA repair protein KU86 at distances up to 10 cm from an adenocarcinoma in a colon resection (graphed here from data reported on one of 8 similarly affected colon resections). ADCA: Adenocarcinoma.