High-dose vs standard radiotherapy in rectal cancer: Effects on tumour response, toxicity, and organ preservation

Figure 1  Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram of study selection.

Figure 2 Forest plots of tumour response outcomes and safety and disease control outcomes. A: Forest plot of clinical complete response; B: Forest plot of clinical complete response after exclusion of Yariv et al[17]; C: Forest plot of pathological complete response; D: Forest plot of tumour regression grade 1-2.

Figure 3 Forest plots of safety and disease control outcomes. A: Forest plot of grade ≥ 3 toxicity; B: Forest plot of organ preservation rates; C: Forest plot of local recurrence; D: Forest plot of distant metastasis.