Post-translational modifications in hepatocellular carcinoma: Linking senescence, metabolic reprogramming, and immune evasion for therapeutic innovation

doi:10.4251/wjgo.v18.i6.118497

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jun 15, 2026; 18(6): 118497
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.118497

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Figure 1 Post-translational modifications orchestrate cellular senescence and immune microenvironment in hepatocellular carcinoma. ATR: Ataxia telangiectasia and Rad3-related; CHK1/2: Checkpoint kinase 1/2; HDAC6: Histone deacetylase 6; MDM2: Mouse double minute 2 homolog; SASP: Senescence-associated secretory phenotype; OGT: O-GlcNAc transferase; LDHA: Lactate dehydrogenase A; EZH2: Enhancer of zeste homolog 2; PD-1: Programmed cell death protein 1; PD-L1: Programmed death-ligand 1; p53: Tumor protein p53; p300: Histone acetyltransferase p300; CBP: CREB-binding protein; NF-κB: Nuclear factor-κB; YBX1: Y-box binding protein 1; ATM: Ataxia telangiectasia mutated; UBA2: SUMO-activating enzyme subunit 2; UBC9: Ubiquitin-conjugating enzyme E2 I.

Citation: Song TX, Rong Y, Ji HM, Wang XS. Post-translational modifications in hepatocellular carcinoma: Linking senescence, metabolic reprogramming, and immune evasion for therapeutic innovation. World J Gastrointest Oncol 2026; 18(6): 118497
URL: https://www.wjgnet.com/1948-5204/full/v18/i6/118497.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i6.118497

Song TX, Rong Y, Ji HM, Wang XS. Post-translational modifications in hepatocellular carcinoma: Linking senescence, metabolic reprogramming, and immune evasion for therapeutic innovation. World J Gastrointest Oncol 2026; 18(6): 118497 [DOI: 10.4251/wjgo.v18.i6.118497]

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