Anti-EGFR treatment resistance in patients with wild-type RAS metastatic colorectal cancer: Three case reports

doi:10.4251/wjgo.v18.i3.114379

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Mar 15, 2026 (publication date) through Mar 12, 2026

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Mar 15, 2026; 18(3): 114379
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.114379

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Figure 1 Clinical and biomarker dynamics correlating with genomic profiles in anti-EGFR treated colorectal cancer cases. A: Case 1; B: Case 2; C: Case 3.

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Figure 2 Computed tomography images of tumor size changes in three cases across different stages.

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Figure 3 KRAS exon 2 gene phenotypes. A: KRAS exon 2 wild-type; B: KRAS exon 2.

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Figure 4 HER-2 immunohistochemistry expression status. A: HER-2 (^-); B: HER-2 (3⁺).

Citation: Wang J, Pei Q, Yu NH. Anti-EGFR treatment resistance in patients with wild-type RAS metastatic colorectal cancer: Three case reports. World J Gastrointest Oncol 2026; 18(3): 114379
URL: https://www.wjgnet.com/1948-5204/full/v18/i3/114379.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i3.114379