Prognostic value of immune-inflammation and nutritional indices in advanced hepatocellular carcinoma patients receiving immunotherapy with compound Kushen injection

Figure 1 Flow chart of the study. ECOG-PS: Eastern Cooperative Oncology Group Performance Status.

Figure 2 Correlation analysis between systemic immune-inflammation index and prognostic nutritional index. A: Correlation analysis between systemic immune-inflammation index and prognostic nutritional index in the control group (P < 0.0001); B: Correlation analysis between systemic immune-inflammation index and prognostic nutritional index the treatment group (P = 0.006). SII: Systemic immune-inflammation index; PNI: Prognostic nutritional index.

Figure 3 Relationship between concomitant ascites and systemic immune-inflammation index/prognostic nutritional index. A: Systemic immune-inflammation index in the control group (P < 0.05); B: Prognostic nutritional index in the control group (P < 0.05); C: Systemic immune-inflammation index in the treatment group (P > 0.05); D: Prognostic nutritional index in the treatment group (P > 0.05). AS: Ascites; SII: Systemic immune-inflammation index; PNI: Prognostic nutritional index.

Figure 4 Receiver operating characteristic curves for differentiating patients with and without ascites according to systemic immune-inflammation index and prognostic nutritional index. A and B: Receiver operating characteristic curves for systemic immune-inflammation index and prognostic nutritional index in the control group; C and D: Receiver operating characteristic curves for systemic immune-inflammation index and prognostic nutritional index in the treatment group. AUC: Area under the receiver operating characteristic curve; CI: Confidence interval.

Figure 5 Waterfall plot of the treatment response of patients with and without ascites following compound Kushen injection treatment. FFKS: Fufang Kushen.

Figure 6 Survival analysis. Survival analysis was performed on all patients who received immunotherapy in combination with compound Kushen injection. A: Overall survival curve of patients in the ascites (AS) and no-AS groups; B: Progression-free survival curve of patients in AS and no-AS groups; C: Overall survival curve of patients grouped by systemic immune-inflammation index-prognostic nutritional index; D: Progression-free survival curve of patients grouped by SII-PNI. AS: Ascites; SII: Systemic immune-inflammation index; PNI: Prognostic nutritional index; PFS: Progression-free survival.