EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance

Figure 1 Ephrin-A signal transduction. A: Structure of ephrinA ligands; B: Structure of ephrinB ligands; C: Eph/Ephrin interaction map. GPI: Glycosylphosphatidylinositol; PDZ: Postsynaptic density 95-Discs large Zonula occludentes-1-protein; SAM: Sterile alpha motif.

Figure 2 Schematic representation of the EFNA1 chromosomal gene. A: mRNA (NM_004428.3) schematic; B: mRNA (NM_182685.2) schematic.

Figure 3 Possible molecular mechanisms by which EFNA1 induces angiogenesis. PI3K: Phosphatidylinositol 3-hydroxy kinase; eNOS: Endothelialnitric oxide synthase; TNF-α: Tumor necrosis factor α; PAK: p21-activated kinase.