Cancer-related microangiopathic hemolytic anemia in patients with advanced gastric cancer: A retrospective single-center analysis

Figure 1 Histopathology of diffuse type gastric adenocarcinoma, patient 2. A: Discohesive tumor cells with a prominent intracytoplasmic mucin vacuole and peripherally displaced and compressed nucleus (signet ring cell morphology) diffusely infiltrate muscular layers of the gastric wall; B and C: Bone marrow core needle biopsy from the right iliac crest with residual hematopoietic elements and diffuse carcinomatous infiltrates composed of pale signet ring cells. Immunohistochemical staining for epithelial cell adhesion molecule is positive confirming the epithelial nature of cell infiltrates. A-C: Original magnification, 400 ×. A and B, hematoxylin and eosin staining.