Histopathological characteristics of needle core biopsy and surgical specimens from patients with solitary hepatocellular carcinoma or intrahepatic cholangiocarcinoma

Figure 1 Schematic of the patient selection procedures. NCB: Needle core biopsy; SR: Surgical resection; HCC: Hepatocellular carcinoma; ICC: Intrahepatic cholangiocarcinoma.

Figure 2 The four-tier score method for interpretation of the IHC staining of the three markers. NCB: Needle core biopsy; SS: Surgical specimen; H&E: Haematoxylin and eosin; CK: Cytokeratin; GPC3: Glypican 3; HepPar1: Hepatocyte paraffin-1; Blue arrow: Scattered positive cells; Red arrow: One positive cluster; Yellow arrow: Numerous positive clusters or massive positive staining.

Figure 3 Receiver operating characteristic showing the accuracy of needle core biopsy diagnosis.