• BRAFV600E mutation
• Case report
• Colon cancer
• Penile metastasis
• Targeted therapy

• magnetic resonance imaging
• penile metastasis
• penis cancer
• prostatic adenocarcinoma
• urologic oncology

• cancer
• metastatic gastric adenocarcinoma
• penile metastasis
• radiation oncoolgy
• unusual metastasis

• Carcinoma of the bladder
• Carcinoma of the penis
• Metastatic carcinoma

• Humans
• Penile Neoplasms/pathology
• Penile Neoplasms/secondary
• Male
• Urinary Bladder Neoplasms/pathology
• Aged
• Middle Aged

• adenocarcinoma of lung
• case report
• metastasis
• penile
• targeted therapy

• Humans
• Male
• Penile Neoplasms/pathology
• China/epidemiology
• Middle Aged
• Tertiary Care Centers
• Aged
• Adult
• Carcinoma, Squamous Cell/pathology
• Neoplasms, Second Primary/epidemiology
• Neoplasms, Second Primary/pathology

• Male
• Humans
• Aged
• Positron Emission Tomography Computed Tomography
• Prostatectomy
• Prostatic Neoplasms/pathology
• Gallium Radioisotopes
• Prostate/pathology
• Retrospective Studies
• Edetic Acid

• bladder metastasis
• clinical case
• gastrointestinal cancer
• haematuria
• penile metastasis

• Metastatic
• PET scan
• Prostate cancer

• Penile metastasis
• prostate cancer
• prostate-specific membrane antigen positron emission tomography/computed tomography
• solitary

Positron emission tomography (PET), typically combined with computed tomography (CT), has become a critical advanced imaging technique in oncology. With concurrently acquired positron emission tomography and computed tomography (PET-CT), a radioactive molecule (radiotracer) is injected in the bloodstream and localizes to sites of tumor because of specific cellular features of the tumor that accumulate the targeting radiotracer. The CT scan provides information to allow better visualization of radioactivity from deep or dense structures and to provide detailed anatomic information. PET-CT has a variety of applications in oncology, including staging, therapeutic response assessment, restaging and surveillance. This series of six review articles provides an overview of the value, applications, and imaging interpretive strategies for PET-CT in the more common adult malignancies. The fourth report in this series provides a review of PET-CT imaging in gynecologic and genitourinary malignancies.

Concurrently acquired positron emission tomography and computed tomography (PET-CT) is an advanced imaging modality with diverse oncologic applications, including staging, therapeutic assessment, restaging and longitudinal surveillance. This series of six review articles focuses on providing practical information to providers and imaging professionals regarding the best use and interpretative strategies of PET-CT for oncologic indications in adult patients. In this fourth article of the series, the more common gynecological and adult genitourinary malignancies encountered in clinical practice are addressed, with an emphasis on Food and Drug Administration (FDA)-approved and clinically available radiopharmaceuticals. The advent of new FDA-approved radiopharmaceuticals for prostate cancer imaging has revolutionized PET-CT imaging in this important disease, and these are addressed in this report. However, [¹⁸F]F-fluoro-2-deoxy-d-glucose (FDG) remains the mainstay for PET-CT imaging of gynecologic and many other genitourinary malignancies. This information will serve as a guide for the appropriate role of PET-CT in the clinical management of gynecologic and genitourinary cancer patients for health care professionals caring for adult cancer patients. It also addresses the nuances and provides guidance in the accurate interpretation of FDG PET-CT in gynecological and genitourinary malignancies for imaging providers, including radiologists, nuclear medicine physicians and their trainees.

• PET
• [18F]-fluorodeoxyglucose
• fluciclovine
• gynecologic malignancy
• penile cancer
• prostate cancer
• prostate specific membrane antigen (PSMA)
• renal cell carcinoma
• testicular cancer
• urothelial carcinoma

Penile metastasis of prostate cancer is rare, with a poor prognosis, and only a limited number of relevant cases have been reported so far. With the application of ¹⁸F-PSMA-1007 PET/CT, the biochemical recurrence of prostate cancer can be detected at an early stage for providing important evidence, facilitating clinical decision-making. Here, we have reported a case of solitary penile metastatic recurrence in the context of mild PSA progression (PSA: 0.072 ng/ml). This case highlights the preferable sensitivity of ¹⁸F-PSMA-1007 PET/CT imaging in prostate cancer.

• 18F-PSMA-1007 PET/CT
• PSA
• castration resistance
• penile metastasis
• prostate cancer

• Hepatic cancer
• Urological surgery

• Carcinoma, Hepatocellular/pathology
• Humans
• Liver Neoplasms/pathology
• Male
• Penile Neoplasms/secondary
• Penis/pathology
• Priapism/etiology

• brachytherapy
• oligometastasis
• penile cancer
• prostate cancer

Epithelioid hemangioendothelioma (EHE) is a rare vascular tumour with an intermediate behaviour between benign hemangioma and malignant angiosarcoma. There is scarce data on the penile EHE’s management and its natural history, as our knowledge is based on few reported cases with a short follow-up period. We present a case report and conducted a literature review, including 17 cases. The relevance of this case report derives from the need for better clinical characterization of patients with penile EHE and the importance of defining the outcomes. We report the case of a 53-year-old male with a 1-year history of sleep-related painful erections. Imaging techniques showed a well-defined hypoechoic and hypervascular solid nodule on the dorsal aspect of the penis. It was surgically removed, and the histopathological study revealed a low-risk EHE of the penis. Follow-up magnetic resonance imaging (MRI) and computed tomography did not demonstrate local recurrence nor metastases. According to the literature review, most of the patients were in their fifth and sixth decades of life at the time of diagnosis and lesions were usually located in the glans. The most common clinical presentation was as a painful mass. Follow-up period ranged from 2 months to 5 years. Three patients showed systemic metastases, two of which died due to cancer. The conclusions from the literature review are limited by the reduced number of cases and the short follow-up. This case report highlights the importance of understanding the diagnosis and treatment of this type of rare non-squamous malignant tumours of the penis. Penile EHE is a malignant vascular tumour that is very rare in this location. The best treatment is local excision, with re-excision or intraoperative margins assessment. Occasionally, systemic chemotherapy and radiation therapy can be useful. There is consensus on the importance of very strict follow-up of these patients.

• Epithelioid hemangioendothelioma (EHE)
• case report
• penile cancer
• penile neoplasms
• penis

• Chemotherapy
• Chimiothérapie
• Metastasis
• Métastase
• Oncologie
• Oncology

Penile metastasis of malignant tumors is a very rare condition, often occurring as a part of systemic metastases, and is therefore associated with a poor prognosis. Although there have been reports of magnetic resonance imaging findings of penile metastasis, longitudinal imaging changes have not been presented previously. We report a case of a 80-year-old male patient with penile metastasis from prostate adenocarcinoma. First magnetic resonance imaging demonstrated multiple penile nodules in the left corpus cavernosum corpora cavernosa, and these nodules were fused and across the septum of the penis, forming an enlarged, diffusely spreading mass on the follow-up exam 5 years later. In this case, a longitudinal evaluation of magnetic resonance imaging demonstrated the course of the extension of the rare penile metastasis.

• Computed tomography
• Magnetic resonance imaging
• Penile metastasis
• Prostate cancer

• Aged
• Choline/analogs & derivatives
• Humans
• Male
• Middle Aged
• Penile Neoplasms/diagnostic imaging
• Penile Neoplasms/secondary
• Positron Emission Tomography Computed Tomography
• Prostatic Neoplasms/pathology

• MRI penis
• Penile malignancy
• Penile prosthesis
• Penile trauma
• Penile urethral carcinoma
• Penile vascular anomalies

• Abscess
• Humans
• Magnetic Resonance Imaging
• Male
• Penile Induration
• Penile Prosthesis
• Penis/diagnostic imaging
• Penis/surgery

• Cancer
• Metastasis
• Oedema
• Penile

• MRI
• Penile cancer
• Penile fracture
• Penis
• Peyronie’s disease

• Cáncer de próstata
• Células pequeñas
• Metastasis
• Metástasis
• Pene
• Penile
• Prostate cancer
• Small cell

• Fluorodeoxyglucose positron emission tomography–computed tomography
• penile metastases
• renal cell carcinoma
• tyrosine kinase inhibitor

Chordomas are rare low malignant neoplasm arising from remnants of the notochord with predilection site of the clivus or the os sacrum. Standard therapy is radical excision and adjuvant radiation. Due to invasive growth and adjacent to vital structures resection is often incomplete, and therefore, local recurrence is frequent. First, to the best knowledge of our authors, we present a 70-year-old man with a recurrent chordoma infiltrating the corpus cavernosum. Asymptomatic recurrence was diagnosed by magnet resonance imaging according to the standard follow-up. Our interdisciplinary tumor board recommended surgical resection. We performed a total penectomy and perineal urethrostomy to achieve negative resection margins and preserve best quality of life for the patient.

Metastasis in penile corpus cavernosum from esophageal squamous carcinoma is a rare but fatal disease, which was reported in cases without series studies.

An 84-year-old male smoker, who had a history of curative resection of esophageal squamous carcinoma 12 months before, presented with aggressive dysuria and penis pain for 1 month. Ultrasonic guided biopsy diagnosed metastatic squamous carcinoma from the primary in the esophagus. The accurately modulated conformal radiotherapy and non-steroidal antiinflammatory drugs achieved to alleviate the penis pain temporarily. But the disease progressed and disseminated in a short period. He died of multiple metastases and cancer cachexia in 4 months.

Primary esophageal cancer metastasis to penile corpus cavernosum refers to short onset time of metastasis, extensive dissemination, bad response to treatment and poor prognosis. Palliative therapy to patients with the disease could achieve temporary local symptom relief, but not prolong survival time. More research is necessary to understand the underlying mechanism of esophagheal metastasis.

• Case report
• Esophageal carcinoma
• Palliative therapy
• Penile metastasis

Although lung cancer has a high propensity for distant metastatic disease, penile metastases from primary lung neoplasms are considered particularly rare. A 71-year-old male presented to our hospital with a rapidly enlarging hard palpable penile mass. MR imaging demonstrated two penile masses centered in the left and right corpus cavernosa. Subsequent CT imaging revealed a spiculated pulmonary mass in the right upper lobe with PET/CT, MRI, and surgical exploration, demonstrating evidence of metastases to the left adrenal gland, right subscapularis muscle, brain, and small bowel. Tissue sampling of lesions in the small bowel, right subscapularis muscle, and penis demonstrated histopathology consistent with an adenosquamous carcinoma which in combination with the appearance of the right upper lobe mass on PET/CT imaging suggested the patient's lung cancer as the primary lesion. Prior to our case, pulmonary adenosquamous carcinoma metastasizing to the penis has only been reported once in the literature. Herein, we report a rare case of penile metastases as the presenting sign of metastatic pulmonary adenosquamous carcinoma characterized with PET/CT and MR imaging.

Despite its rich vasculature, the penis is rarely involved by metastasis. Since the first description of penile metastasis in 1870, fewer than 500 cases have been reported in the literature. The pelvic organs are the main source of primary tumors that metastasize to the penis.

We report a case of a 46-year-old Arabic man who presented with erectile dysfunction and painful induration of the penile root. Eight months ago, he had undergone abdomino-perineal resection for rectal adenocarcinoma after neo-adjuvant chemotherapy. The histological evaluation of the resected specimen disclosed a ypT3N0 tumor with a poor therapeutic response (around 5%). An adjuvant chemotherapy by XELOX (oxaliplatin plus capecitabine) regimen has been prescribed for the patient. The magnetic resonance imaging (MRI) showed tumoral infiltration of penile structures and a biopsy of the corpora cavernosa was performed. The histological examination disclosed a penile metastasis from the patient’s previous rectal adenocarcinoma. The patient is still alive and continues his adjuvant therapy.

Penile secondary tumors are very rare and usually occur in patients with advanced tumor stages. A diagnosis of penile metastasis should be considered in patients with a history of malignancies who present with genitourinary symptoms. These patients have a dismal prognosis as they often die in the year after the diagnosis.

• Adenocarcinoma
• Metastasis
• Pathology
• Penis

• case report
• lung cancer
• metastasis
• penile cancer
• perineal pain

• Carcinoma, Adenosquamous/diagnostic imaging
• Carcinoma, Adenosquamous/drug therapy
• Carcinoma, Adenosquamous/secondary
• Carcinoma, Adenosquamous/surgery
• Fatal Outcome
• Humans
• Lung Neoplasms/diagnostic imaging
• Lung Neoplasms/drug therapy
• Lung Neoplasms/pathology
• Male
• Middle Aged
• Penile Neoplasms/diagnostic imaging
• Penile Neoplasms/drug therapy
• Penile Neoplasms/secondary
• Penile Neoplasms/surgery

• Bladder urothelial carcinoma
• Metastasis
• Pagetoid spread
• Penis
• Warthy lesion

We describe three cases of advanced penile cancer associated with HIV infection.

Advanced penile cancer associated with VIH infection were discovered in three patients aged respectively 47, 56 and 40. The prognosis was extremely poor. Two patients died without receiving any treatment and one patient was lost to follow-up after refusing all treatment proposed.

There appears to be a link between HIV infection and penile cancer with concomitant HIV infection worsening the prognosis of the disease.