• Helicobacter pylori
• Enzymatic activity
• FAS-II
• FabI
• Protein production

• Yıldız Technical University Scientific Research Projects Coordination Department. Project Number: FBA-2021-4233 Yildiz Teknik Üniversitesi

• Helicobacter pylori
• cohort study
• metabolic dysfunction-associated steatotic liver disease
• non-alcoholic fatty liver disease

• CagA
• Helicobacter pylori
• Liver fibrosis
• Metabolic dysfunction associated steatotic liver disease
• Non-alcoholic fatty liver disease
• Vibration controlled transient elastography

• Humans
• Male
• Female
• Middle Aged
• Helicobacter pylori
• Antigens, Bacterial/genetics
• Bacterial Proteins/genetics
• Adult
• Liver Cirrhosis/microbiology
• Helicobacter Infections/complications
• Helicobacter Infections/microbiology
• Risk Factors
• Elasticity Imaging Techniques
• Gastroscopy
• Non-alcoholic Fatty Liver Disease/microbiology
• Non-alcoholic Fatty Liver Disease/complications
• Biopsy
• Virulence
• Virulence Factors/genetics

• Humans
• Male
• Female
• Lipase/genetics
• Membrane Proteins/genetics
• Middle Aged
• Helicobacter Infections/complications
• Helicobacter Infections/genetics
• Helicobacter pylori
• Adult
• Cross-Sectional Studies
• Retrospective Studies
• Fatty Liver/genetics
• Fatty Liver/complications
• Alleles
• Polymorphism, Single Nucleotide
• Dyspepsia/microbiology
• Dyspepsia/genetics
• Dyspepsia/complications
• Liver/pathology
• Liver/metabolism
• Acyltransferases
• Phospholipases A2, Calcium-Independent

• Fundacion HA Barcelo

• Diagnosis
• Eradication
• Gastric cancer
• Helicobacter pylori
• Infection

• Helicobacter Infections/diagnosis
• Helicobacter Infections/drug therapy
• Helicobacter Infections/epidemiology
• Helicobacter Infections/therapy
• Humans
• Helicobacter pylori
• Africa/epidemiology
• Consensus
• Prevalence

• Adenocarcinoma
• Diet
• H. pylori
• Stomach

• Humans
• Stomach Neoplasms/genetics
• Stomach Neoplasms/etiology
• Stomach Neoplasms/epidemiology
• Risk Factors
• Genetic Predisposition to Disease
• Environmental Exposure/adverse effects

• Rats
• Animals
• Micelles
• Helicobacter pylori
• Guanidine/pharmacology
• Escherichia coli
• Polymers/pharmacology
• Polymers/chemistry
• Anti-Bacterial Agents/pharmacology
• Hydrogen-Ion Concentration
• Acetates

• Humans
• Helicobacter
• Helicobacter pylori
• Helicobacter Infections/epidemiology
• Gastritis
• Machine Learning

Genetic variants of Helicobacter pylori (H. pylori) are involved in gastric cancer occurrence. Single nucleotide polymorphisms (SNPs) of H. pylori that are associated with gastric cancer have been reported. The combined effect of H. pylori SNPs on the risk of gastric cancer remains unclear.

To assess the performance of a polygenic risk score (PRS) based on H. pylori SNPs in predicting the risk of gastric cancer.

A total of 15 gastric cancer-associated H. pylori SNPs were selected. The associations between these SNPs and gastric cancer were further validated in 1022 global strains with publicly available genome sequences. The PRS model was established based on the validated SNPs. The performance of the PRS for predicting the risk of gastric cancer was assessed in global strains using quintiles and random forest (RF) methods. The variation in the performance of the PRS among different populations of H. pylori was further examined.

Analyses of the association between selected SNPs and gastric cancer in the global dataset revealed that the risk allele frequencies of six SNPs were significantly higher in gastric cancer cases than non-gastric cancer cases. The PRS model constructed subsequently with these validated SNPs produced significantly higher scores in gastric cancer. The odds ratio (OR) value for gastric cancer gradually increased from the first to the fifth quintile of PRS, with the fifth quintile having an OR value as high as 9.76 (95% confidence interval: 5.84-16.29). The results of RF analyses indicated that the area under the curve (AUC) value for classifying gastric cancer and non-gastric cancer was 0.75, suggesting that the PRS based on H. pylori SNPs was capable of predicting the risk of gastric cancer. Assessing the performance of the PRS among different H. pylori populations demonstrated that it had good predictive power for cancer risk for hpEurope strains, with an AUC value of 0.78.

The PRS model based on H. pylori SNPs had a good performance for assessment of gastric cancer risk. It would be useful in the prediction of final consequences of the H. pylori infection and beneficial for the management of the infection in clinical settings.

• Polygenic risk scores
• Helicobacter pylori
• Gastric cancer
• Single nucleotide polymorphism

• H. pylori
• adenocarcinoma
• diet
• stomach

• Humans
• Risk Factors
• Stomach Neoplasms/etiology
• Stomach Neoplasms/genetics
• United States

• R38 CA245095 NCI NIH HHS
• 1R38CA245095-01A1 NCI NIH HHS

Background: In Arizona Helicobacter pylori prevalence of infection among Navajo adults is about 62% and gastric cancer incidence rate is 3–4 times higher than that of the non-Hispanic White population. Aim: The aim of this study was to estimate the prevalence of specific H. pylori virulence factors (cagA and vacA) among Navajo patients undergoing and their association with gastric disease. Methods: Virulence genes, cagA and vacA, in H. pylori were investigated in gastric biopsies from 96 Navajo patients over age 18 who were undergoing esophagogastroduodenoscopy. Biopsies from the antrum and fundus were used for molecular characterization to determine cagA type and number of EPIYA motifs and presence of alleles in the signal (s) and medium (m) regions of the vacA gene. Results: H. pylori infection was found in 22.9% of the biopsy samples. The cagA gene amplified in 57.6% of samples and showed a predominant “Western cagA” type, with the EPIYA-ABC motif (45.4%), most prevalent. The vacA allele s1bm1 was the most prevalent (54.5%). Conclusions: H. pylori genotypes were predominantly cagA Western-type and ABC EPIYA motifs. The vacA s1bm1 genotype was the most prevalent and seemed to be associated with gastritis. American Indian/Alaska Native populations are at higher risk for gastric cancer. It is important to identify genotypes of H. pylori and virulence factors involved in the high prevalence of H. pylori and associated disease among the Navajo population.

• Helicobacter pylori
• celiac disease
• chronic gastritis and peptic ulcer disease
• dysbiosis
• gastric cancer and gastrectomy
• inflammatory bowel disease
• osteoporosis

• Bone Density
• Bone Diseases, Metabolic
• Female
• Fractures, Bone/complications
• Gastrointestinal Diseases/complications
• Humans
• Male
• Osteoporosis/epidemiology
• Osteoporosis/etiology

• age
• body mass index
• sex
• helicobacter pylori
• pepsinogen

• Asymptomatic Diseases
• Biomarkers/blood
• China/epidemiology
• Female
• Follow-Up Studies
• Helicobacter Infections/blood
• Helicobacter Infections/epidemiology
• Humans
• Incidence
• Male
• Pepsinogen C/blood
• Retrospective Studies

• Drug packaging
• Drug therapy
• Helicobacter pylori
• Interrupted time series analysis
• Proton-pump inhibitors

• Diagnostic yield
• Endoscopy
• Helicobacter pylori
• Histology
• Rapid urease test

This study aimed to determine the association of Helicobacter pylori (H. pylori) infection with pregnancy-related diseases and fetal development in women with diabetes in pregnancy (DIP).

All the participants were recruited before 16 weeks of gestation. According to their medical history and the results of a 75-g oral glucose tolerance test at the 24^th week of pregnancy, the participants were divided into a normal control group (NC group), a gestational diabetes mellitus group (GDM group), and a pre-pregnancy diabetes mellitus group (PGDM group). According to the results of an H. pylori serum antibody detection test, each group was further divided into two subgroups: an H. pylori positive subgroup (HP+ subgroup) and an H. pylori negative group (HP- subgroup). The incidences of pregnancy-related diseases, the fetal developmental status, and the newborn status were compared among the groups.

This study recruited 356 pregnant women. The infection rates of type I H. pylori were significantly higher in the GDM group and the PGDM group than in the NC group (χ²=6.949, P=0.031). With the exception of the NC-HP+ subgroup, there were higher incidences of pregnancy-related diseases in the HP+ subgroups than in the HP− subgroups (P<0.05). Furthermore, the incidences of pregnancy-induced hypertension (PIH), preeclampsia, and premature delivery were significantly higher in the GDM-HP+ subgroup and the PGDM-HP+ subgroup than in the NC-HP+ subgroup (P<0.05). At the end of pregnancy, all 3 HP− subgroups showed better fetal development than the HP+ subgroups (P<0.05), and the NC-HP+ subgroup showed better fetal development than the GDM-HP+ and PGDM-HP+ subgroups (P<0.05). Meanwhile, the PGDM-HP+ subgroup showed poor fetal development, even in the 2^nd trimester of pregnancy.

H. pylori infection is extremely common in DIP. For women with DIP, infection with H. pylori can increase the risks of pregnancy-related diseases and poor fetal development. H. pylori screening and eradication therapy before pregnancy may aid in preventing pregnancy-related diseases and improve fetal development.

• Helicobacter pylori (H. pylori)
• diabetes in pregnancy (DIP)
• fetal development
• pregnancy-related diseases

• Helicobacter pylori
• cohort study
• dyslipidemia
• eradication

• Cohort study
• Helicobacter pylori
• Incidence
• Osteoporosis

This review considers the data on Helicobacter pylori (H. pylori), which have been accumulated over 40 years since its description as an etiological factor in gastrointestinal diseases. The majority of modern publications are devoted to the study of the pathogenic properties of the microorganism in the development of chronic gastritis, peptic ulcer disease, and gastric cancer, as well as methods for its eradication. However, in recent years, there have been more and more studies which have suggested that H. pylori has a beneficial, or potentially positive, effect on the human body. The authors have attempted to objectively analyze the information accumulated in the literature on H. pylori. Some studies consider it as one of the recently identified human bacterial pathogens, and special attention is paid to the evidence suggesting that it is probably part of the composition of the human microbiome as a commensal (commensal from French to English is a table companion) or even a symbiont. The presented data discussing the presence or absence of the effect of H. pylori on human health suggest that there is an apparent ambiguity of the problem. The re-assessment of the data available on H. pylori infection is important in order to answer the question of whether it is necessary to create a program of mass H. pylori eradication or to apply a more personalized approach to treating patients with H. pylori-associated gastrointestinal diseases and to perform eradication therapy.

• Helicobacter pylori
• Pathogen
• Commensal
• Microbiome
• Peptic ulcer
• Gastric cancer
• Asthma
• Inflammatory bowel diseases

• Anti-Bacterial Agents/therapeutic use
• Gastritis, Atrophic/drug therapy
• Helicobacter Infections/diagnosis
• Helicobacter Infections/drug therapy
• Helicobacter pylori
• Humans
• Peptic Ulcer/drug therapy
• Stomach Neoplasms/drug therapy

• Helicobacter pylori
• H. pylori adhesins
• HpaA
• adhesion
• vaccines

• Helicobacter pylori
• antibiotic resistance
• eradication
• metronidazole

• BONE MINERAL DENSITY
• ESTROGENS
• FRACTURES
• HELICOBACTER PYLORI
• OSTEOPOROSIS

• Algeria
• Helicobacter pylori
• digestive symptoms
• gastric pathology
• infection

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Algeria/epidemiology
• Child
• Child, Preschool
• Digestive System Diseases/epidemiology
• Digestive System Diseases/microbiology
• Female
• Helicobacter Infections/epidemiology
• Helicobacter pylori/isolation & purification
• Humans
• Infant
• Infant, Newborn
• Male
• Middle Aged
• Retrospective Studies
• Young Adult

Acute perforated duodenal ulcers are considered one of the most encountered emergency surgical conditions leading to mortality. Different approaches have been proposed for management based on the clinical status of the patient. The use of omental patch closure is widely accepted either via an open or laparoscopic approach. However, not all patients are candidates owing to the availability and viability of the greater omentum. In these patients, the falciform ligament can be used as an alternative and efficient method for repair. In this case, we present a male patient with a perforated ulcer in the first part of the duodenum which was managed by falciform ligament patch instead of the usual omental patch. In cases of a deficient or unhealthy greater omentum, or if it cannot be brought in the upper part of the abdominal cavity due to severe adhesions, the falciform ligament can be used efficiently in the closure of perforated duodenal ulcer.

• case reports
• duodenal ulcers
• falciform ligament
• omental patch
• perforation

The effect of standard therapeutic strategies on Helicobacter pylori infection is diminished over time owing to the emergence of drug resistant strains. In this study, we would like to confirm the enhanced effect of L. paracasei HP7, which has been reported to exert antibacterial and gastric mucosal protective effects, in combination with Perilla frutescens var. acuta (P. frutescens)and Glycyrrhiza glabra (G. glabra) extracts.

P. frutescens extract and G. glabra extract were found to inhibit the growth of H. pylori in a concentration-dependent manner, and the combination of L. paracasei HP7 and P. frutescens extract and G. glabra extract effectively inhibited H. pylori from attaching to AGS a gastric epithelial cells. Moreover, L. paracasei HP7 complex mixture containing P. frutescens and G. glabra extracts has been shown to inhibit H. pylori virulence genes such as AlpA, CagA, FlaA and UreA. When H. pylori-infected mice were administered a complex mixture of L. paracasei HP7 containing P. frutescens and G. glabra extract, the infection rate of H. pylori was significantly reduced. In addition, the L. paracasei HP7 complex mixture significantly reduced serum IL-8 levels and stomach inflammation in H. pylori infected mice.

These results suggest that a complex mixture of L. paracasei HP7 containing P. frutescens and G. glabra extracts may be an alternative to treating diseases caused by H. pylori infection.

• Glycyrrhiza glabr
• HP7
• Helicobacter pylori
• Lactobacillus paracasei
• Perilla frutescens var. acuta

• Helicobacter pylori
• ancestry
• co-evolution
• gastric cancer
• risk predictor
• virulence genes

• Clarithromycin
• Drug resistance
• Genetic polymorphism
• Helicobacter pylori
• Parental history

Chronic systemic inflammation is an important causative factor in the pathogenesis of atherosclerosis. However, the effect of chronic Helicobacter pylori (Hp) infection on arterial stiffness, a predictor of cardiovascular events, remains unclear. We evaluated the association between Hp infection and arterial stiffness in asymptomatic healthy individuals.

Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI). We included subjects who underwent CAVI and anti-Hp IgG antibody evaluations, simultaneously, between March 2013 and July 2017. Demographic characteristics and metabolic and cardiovascular parameters were compared with respect to anti-Hp IgG antibody status. Multivariable logistic regression analyses were performed to determine the effect of Hp-seropositivity and conventional cardiovascular risk factors on arterial stiffness.

Of 2,251 subjects, 1,326 (58.9%) were included in the Hp-seropositive group. Median age (P < 0.001) and systolic blood pressure (P = 0.027) were significantly higher in the Hp-seropositive than in the Hp-seronegative group. Levels of LDL-cholesterol were significantly higher in the Hp-seropositive than in the Hp-seronegative group (P = 0.016). Other serum metabolic parameters were not significantly different between the two groups. The median CAVI value and the proportion of subjects with a CAVI ≥ 8 were significantly higher in the Hp-seropositive than in the Hp-seronegative group (both P < 0.001). On multivariable logistic regression analyses, Hp-seropositivity, age, body mass index, waist circumference, smoking, hypertension, diabetes mellitus, and dyslipidemia were significantly associated with high CAVI values. In the subgroup analysis conducted according to age group, a tendency towards an increased association between Hp-seropositivity and CAVI was observed with increasing age, even though the difference did not reach the statistical significance.

Hp-seropositivity was significantly associated with arterial stiffness. Hp infection may contribute to the development of cardiovascular diseases.

• CircRNA
• Functions
• Gastric cancer
• Laboratory detection methods
• Prevalence situation

• Animals
• Gene Expression Regulation, Neoplastic
• Humans
• MicroRNAs/genetics
• Prevalence
• RNA, Circular/genetics
• Stomach Neoplasms/epidemiology
• Stomach Neoplasms/genetics
• Stomach Neoplasms/pathology
• Transcriptome

• National Natural Science Foundation of China

• adverse events
• elderly patients
• eradication
• helicobacter pylori (h. pylori)
• safety

• Age Factors
• Aged
• Aged, 80 and over
• Aging
• Anti-Bacterial Agents/therapeutic use
• Chronic Disease
• Drug Therapy, Combination
• Female
• Gastritis/etiology
• Helicobacter Infections/complications
• Helicobacter Infections/drug therapy
• Helicobacter pylori
• Humans
• Male
• Middle Aged
• Peptic Ulcer/etiology
• Proton Pump Inhibitors/therapeutic use
• Retrospective Studies

The correlation between Helicobacter pylori (H. pylori) and gastroesophageal reflux disease (GERD) is complex. Some studies showed a protective role of H. pylori infection against GERD. This study was aimed at assessing the role of H. pylori infection in GERD utilizing a large cohort of patients diagnosed with GERD.

All patients who underwent gastroscopy for an indication of GERD during the study period between 2015 and 2017 at the EMMS Nazareth Hospital were considered eligible for the study and therefore were included. H. pylori infection was determined by the rapid urease test or histology. Severity of esophagitis was assessed using the Los Angeles classification. Univariate analysis was performed to figure out differences between patients according to H. pylori infection status. Multivariate regression analysis was conducted to illustrate the predictors of positivity for H. pylori infection.

2,508 GERD patients were included with a median age of 49.42 ± 17.96 years. H. pylori infection was detected in 299 (11.9%) patients. GERD patients with H. pylori infection were found to be younger (48.83 ± 17.42 years versus 44.57 ± 17.69 years, p < 0.001), have the tendency to smoke more (1406 (63.6%) versus 266 (89.0%), p < 0.001), and use more proton pump inhibitors or PPIs (1314 (59.5%) versus 242 (80.9%), p < 0.001). In multivariate regression analysis, age (OR 0.987, p < 0.001), smoking status (OR 0.190, p < 0.001), use of ASA/NSAIDs (OR 1.652, p = 0.004), and use of statins (OR 0.499 (95%CI 0.295-0.846), p = 0.010) were found significant among H. pylori-positive individuals. H. pylori-positive subjects have less severe esophagitis and more hiatus hernia.

Patients with GERD and H. pylori infection were significantly younger, tended to smoke more, and used more PPIs and had significantly lower grades of esophagitis compared to noninfected ones.

• AGS cells
• HP7
• Helicobacter pylori
• Kimchi
• Lactobacilllus paracasei

• Eradication treatment
• Gastric lymphoma
• Helicobacter pylori
• Linfoma MALT
• Linfoma gástrico
• MALT lymphoma
• Tratamiento erradicador

To assess the association between Helicobacter pylori (H. pylori) infection and insulin resistance among pregnant Sudanese women attending Saad Abuelela hospital (Khartoum). A cross-sectional study was conducted from 1st July 2017 to 31st January 2018. One hundred and sixty-six women were enrolled and underwent testing for H. pylori IgG antibodies using specific ELISA kits. The Quantitative insulin sensitivity check index (QUICKI) was computed from the fasting insulin and glucose levels.

Median age, gravidity and gestational age were 27 years, 2 and 26 weeks, respectively. Twenty (12%) women were found to have gestational diabetes mellitus (GDM). H. pylori IgG seroprevalence was 66.0% among the study population. Univariate analysis showed that H. pylori-seropositivity was significantly higher among women who have GDM while Log (Homeostatic Model Assessment-β) HOMA-B% was lower (P value = 0.038, and 0.028) respectively. There was no difference between the GDM group and the other group in terms of demographics, body mass index, haemoglobin and QUICKI index results. In multivariate analysis, a higher prevalence of H. pylori was associated with GDM (OR = 2.8, 95% CI  1.1–7.5, P = 0.036). The current study concludes that an increased prevalence of H. pylori is a risk factor for the development of GDM.

• H. pylori
• Insulin resistance
• Pregnancy
• Sudan

• AIDS
• Colonoscopy
• Endoscopy
• HAART
• HIV

• Cag A
• Gastric cancer
• Gastric ulcers
• Gastritis
• Helicobacter pylori
• Vac A

• Cohort study
• Helicobacter pylori
• Incidence
• Nonalcoholic fatty liver disease

• biopsies
• eradication
• rescue

• Anti-Bacterial Agents/chemistry
• Anti-Bacterial Agents/pharmacology
• Drug Resistance, Bacterial/drug effects
• Helicobacter Infections/drug therapy
• Helicobacter pylori/drug effects
• Humans
• Microbial Sensitivity Tests
• Proton Pump Inhibitors/chemistry
• Proton Pump Inhibitors/pharmacology

• Helicobacter pylori
• colorectal neoplasm
• insulin resistance
• metabolic syndrome

Helicobacter pylori (H. pylori) infection is related to peptic ulcer diseases and gastric cancer and eradication of H. pylori should be expected to decrease the risk of their development. Factors affecting H. pylori eradication are antibiotic resistance, CYP2C19 genotypes, drug regimen and patient compliance. Increment of omeprazole and amoxicillin dosage in clarithromycin-containing triple therapy regimen may overcome these problems and may be a better choice than the conventional clarithromycin-containing triple therapy regimen.

To compare the eradication rates with modified triple therapy (MTT) and standard triple therapy (STT) as first-line treatment.

The study was an open label, multicenter, randomized controlled trial. A total of 170 patients infected with H. pylori diagnosed by rapid urease test were randomly assigned into 2 groups. The first was treated with a 14-day MTT (20 mg omeprazole t.i.d., 500 mg amoxicillin t.i.d., and 500 mg clarithromycin b.i.d.) and the second with a 14-day STT (20 mg omeprazole b.i.d., 1000 mg amoxicillin b.i.d., and 500 mg clarithromycin b.i.d.). H. pylori eradication was evaluated by ¹⁴C-urea breath test. CYP2C19 genotypes, clarithromycin resistance, side effects and patient compliance were also recorded.

There were 85 patients in each group. The H. pylori eradication rate in the MTT group was 84.7% by ITT analysis and 91.1% by PP analysis, compared to the STT group values of 76.5% and 87.8% (p = 0.18 and 0.51), respectively. CYP2C19 genotypes and patient compliance were similar in both groups. Prevalence of clarithromycin resistance was 7.0%. Side effects were all mild with no significant differences between the twogroups.

MTT is not superior to STT. From this study, MTT may not be recommended as the first-line treatment for H. pylori infection in Thailand because eradication rates proved to be less than 90% by ITT analysis.

• Modified high dose
• omeprazole
• amoxicillin
• triple therapy
• Helicobacter pylori eradication
• Thailand