Current status of endoscopic treatment for esophageal diverticulum based on diverticular peroral endoscopic myotomy

Table 1 The initial search yielded 20 articles, of which 6 met the inclusion criteria after excluding unrelated studies[7,74,83,88-90]

No.	Publication year	Researchers	Study type	Diverticulum type	Type of poem	Technical/clinical success rate and follow-up duration	Adverse events
1	2019	Yang et al[7]	Multicenter and retrospective	7 ZD, 1 MED, 3 ED	D-POEM	90.9%/100% (patients who successfully underwent POEM) (12 months)	None
2	2019	Maydeo et al[74]	Prospective	20 ZD, 5 ED	D-POEM	100%/86% (12 months)	None
3	2020	Basile et al[83]	Retrospective	7 MED and ED	POEM + S (all diverticulum are associated with EMD)	100%/85.71% (12 months)	None
4	2021	Zeng et al[88]	Retrospective	2 ZD, 5 MED, 3 ED	D-POEM (POEM + S performed for ED with achalasia)	100%/90% (11.0 months) (IQR: 10.25-17.25 months)	Emphysema (n = 1, 10%)
5	2022	Samanta et al[89]	Retrospective	3ZD, 2ED	POEM (POEM + S for ED, larger diverticulum underwent POES)	100%/100% (9.33 months) (range: 3.27-11 months)	Emphysema (n = 1, 20%); mucosal injury (n = 1, 20%)
6	2024	Ren et al[90]	Multicenter and prospective	12 ZD, 12 MED, 10 ED	D-POEM (POEM + S performed for diverticulum with coexistent achalasia)	100%/88.2% (25 months) (range: 3-68 months)	Emphysema (n = 5, 14.7%); mucosal injury (n = 1, 2.9%)

ZD: Zenker’s diverticulum; ED: Epiphrenic diverticulum; MED: Mid-esophageal diverticulum; D-POEM: Diverticular peroral endoscopic myotomy; EMD: Esophageal motility disorders; POES: Peroral endoscopic septotomy; IQR: Interquartile range.