Comparison of different anastomosis methods in laparoscopically assisted left hemicolectomy for colon cancer

Table 1 Comparison of the clinical data of the end-to-side anastomosis and side-to-side anastomosis groups, n (%)

Parameter	Group ESA	Group SSA	χ²	P value
n = 334	146 (43.7)	188 (56.3)
Age (year)			0.183	0.669
≤ 60	71 (48.6)	87 (46.3)
> 60	75 (51.4)	101 (53.7)
Sex			0.001	0.991
Male	90 (61.6)	116 (62.7)
Female	56 (38.4)	72 (38.3)
Patient center			0.858	0.354
Xiamen	42 (28.8)	63 (33.5)
Fuzhou	104 (71.2)	125 (66.5)
BMI (kg/m2)			3.728	0.054
≤ 22	56 (38.4)	92 (48.9)
> 22	90 (61.6)	96 (51.1)
Tumor location			3.171	0.075
Descending	39 (26.7)	47 (36.7)
Descending-sigmoid junction	107 (73.3)	81 (63.3)
TNM stage			0.072	0.789
II	86 (58.9)	108 (57.4)
III	60 (41.1)	80 (42.6)
Histological differentiation			0.652	0.419
Medium/high	128 (87.7)	159 (84.6)
Low/mucinous/signet ring cell carcinoma	18 (12.3)	29 (15.4)
Size of primary tumor (cm)			2.414	0.12
≤ 5.0	102 (69.9)	116 (61.7)
> 5.0	44 (30.1)	72 (38.3)
High ligation inferior mesenteric artery			2.569	0.109
Yes	75 (51.4)	80 (42.6)
No	71 (48.6)	108 (57.4)
Preoperative intestinal obstruction			0.003	0.96
Yes	23 (15.8)	30 (16.0)
No	123 (84.2)	158 (84.0)
CEA (ng/mL)			0.795	0.373
≤ 5.0	91 (62.3)	126 (67.0)
> 5.0	55 (37.7)	62 (33.0)
Hb (g/L)			3.495	0.062
≤ 10	9 (6.2)	23 (12.2)
> 10	137 (93.8)	165 (87.8)		≤ 0.001
Postoperative chemotherapy (half a year)			0.032	0.858
Yes	77 (52.7)	101 (53.7)
No	69 (47.3)	87 (46.3)

ESA: End-to-side anastomosis; SSA: Side-to-side anastomosis; CEA: Carcinoembryonic Antigen; Hb: Hemoglobin; BMI: Body mass index.

Table 2 Comparison of the intraoperative and postoperative conditions, n (%)/mean ± SD

Parameter	Group ESA	Group SSA	t	P value
n = 334	146 (43.7)	188 (56.3)
Operation time (minute)	197.1 ± 57.7	218.6 ± 67.5	4.298	0.039
Length of bowel resection (cm)	20.1 ± 5.4	19.8 ± 5.5	-0.331	0.741
Blood loss (mL)	73.1 ± 35.9	70.5 ± 30.3	-0.703	0.482
Postoperative 48 hours pain score	4.0 ± 1.2	4.1 ± 1.2	0.213	0.832
Postoperative first exhaust time (day)	3.1 ± 0.7	3.2 ± 0.8	0.841	0.401
Postoperative hospital stay (day)	10.8 ± 6.0	11.3 ± 5.0	-0.64	0.523
Lymph node dissection	22.0 ± 11.5	24.5 ± 12.6	1.82	0.070

ESA: End-to-side anastomosis; SSA: Side-to-side anastomosis.

Table 3 Comparison of the complications, n (%)

Parameter	Group ESA	Group SSA	χ²	P value
n = 334	146 (43.7)	188 (56.3)
SIRS	23 (15.8)	40 (21.3)	0.638	0.201
Anastomotic bleeding	3 (2.1)	9 (4.8)	1.771	0.183
Anastomotic leakage	3 (2.1)	8 (4.3)	1.249	0.264
Anastomotic stenosis	2 (1.4)	4 (2.1)	0.268	0.605
Urinary injury	1 (0.7)	3 (1.6)	0.576	0.448
Pancreatic injury	1 (0.7)	4 (2.1)	1.160	0.281
Splenic laceration	0 (0.0)	7 (3.7)	5.553	0.018
Adhesive intestinal obstruction1	3 (1.4)	4 (3.3)	0.022	0.882
Adhesive intestinal obstruction2	5 (3.4)	6 (3.2)	0.014	0.906
Adhesive intestinal obstruction3	9 (6.2)	7 (3.7)	1.074	0.300

¹Occured within 6 months.

²Occured within 12 months.

³Occured within 24 months.

ESA: End-to-side anastomosis; SSA: Side-to-side anastomosis; SIRS: Systemic inflammatory response syndrome.