©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Oct 16, 2017; 9(10): 514-520
Published online Oct 16, 2017. doi: 10.4253/wjge.v9.i10.514
Published online Oct 16, 2017. doi: 10.4253/wjge.v9.i10.514
Oral esomeprazole vs injectable omeprazole for the prevention of hemorrhage after endoscopic submucosal dissection
Takashi Uchiyama, Takuma Higurashi, Atsushi Nakajima, Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama city, Kanagawa Prefecture 236-0042, Japan
Takashi Uchiyama, Hitoshi Kuriyama, Yasuo Hata, Department of Gastroenterology, Chigasaki Municipal Hospital, Chigasaki city, Kanagawa Prefecture 235-0042, Japan
Yoshinobu Kondo, Department of Endocrinology and Metabolism, Chigasaki Municipal Hospital, Chigasaki city, Kanagawa Prefecture 235-0042, Japan
Author contributions: Uchiyama T collected and analyzed the data, and drafted the manuscript; Higurashi T provided analytical oversight; Nakajima A supervised the study; Kuriyama H and Hata Y revised the manuscript for important intellectual content; Kondo Y offered the technical support; authors have read and approved the final version to be published.
Institutional review board statement: Ethics committee approval was received for this study from the ethics committee of Chigasaki Municipal Hospital.
Informed consent statement: All the treatment procedures were performed after obtaining informed consent in writing from the patients.
Conflict-of-interest statement: No conflict of interest was declared by the authors.
Data sharing statement: No additional data are available.
Correspondence to: Takashi Uchiyama, MD, PhD, Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawaku, Yokohama city, Kanagawa 236-0004, Japan. tuchiyama-ykh@umin.ac.jp
Telephone: +81-45-7872640 Fax: +81-45-7843546
Received: March 22, 2017
Peer-review started: March 23, 2017
First decision: April 17, 2017
Revised: May 19, 2017
Accepted: July 14, 2017
Article in press: July 17, 2017
Published online: October 16, 2017
Processing time: 205 Days and 11.1 Hours
Peer-review started: March 23, 2017
First decision: April 17, 2017
Revised: May 19, 2017
Accepted: July 14, 2017
Article in press: July 17, 2017
Published online: October 16, 2017
Processing time: 205 Days and 11.1 Hours
Core Tip
Core tip: Proton pump inhibitors (PPIs) have been reported to be effective for suppressing hemorrhage after endoscopic submucosal dissection (ESD); however, it remains unclear whether oral PPI therapy or injectable PPI therapy is preferable. The results of the present study indicate that oral effectiveness of oral esomeprazole therapy is a useful alternative to injectable PPI therapy for the prevention of hemorrhage after ESD.