©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Mar 10, 2016; 8(5): 273-275
Published online Mar 10, 2016. doi: 10.4253/wjge.v8.i5.273
Published online Mar 10, 2016. doi: 10.4253/wjge.v8.i5.273
Raman spectroscopy for early real-time endoscopic optical diagnosis based on biochemical changes during the carcinogenesis of Barrett’s esophagus
Hong Shi, Su-Yu Chen, Department of Gastrointestinal Endoscopy, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, Fujian Province, China
Kai Lin, Department of General Surgery, Fuzhou Seventh Hospital, Fuzhou 350014, Fujian Province, China
Author contributions: Shi H and Chen SY were responsible for the study concept and design; all authors conducted endoscopic operations together; Chen SY and Lin K drafted the manuscript; Shi H revised and finalized the manuscript.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Correspondence to: Hong Shi, MD, Department of Gastrointestinal Endoscopy, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, No 420 FuMa Road, Fuzhou 350014, Fujian Province, China. endoshihong@hotmail.com
Telephone: +86-591-83660063 Fax: +86-591-83660063
Received: August 27, 2015
Peer-review started: October 1, 2015
First decision: November 30, 2015
Revised: December 16, 2015
Accepted: January 8, 2016
Article in press: January 11, 2016
Published online: March 10, 2016
Processing time: 190 Days and 3.8 Hours
Peer-review started: October 1, 2015
First decision: November 30, 2015
Revised: December 16, 2015
Accepted: January 8, 2016
Article in press: January 11, 2016
Published online: March 10, 2016
Processing time: 190 Days and 3.8 Hours
Core Tip
Core tip: Raman spectroscopy is a very sensitive tool to detect subtle biochemical and molecular changes, which is crucial for differentiating nondysplastic from high-grade dysplastic Barrett’s esophagus. With an increased accuracy of updated algorithms and a real time automatic analysis system, Raman spectroscopy is expected to improve in vivo precancerous diagnosis and tissue characterization of Barrett’s esophagus.