Kanazawa R, Sai JK, Ito T, Miura H, Ishii S, Saito H, Tomishima K, Shimizu R, Sato K, Hayashi M, Watanabe S, Shiina S. Prior minimal endoscopic sphincterotomy to prevent pancreatitis related to endoscopic balloon sphincteroplasty. World J Gastrointest Endosc 2016; 8(18): 663-668 [PMID: 27803773 DOI: 10.4253/wjge.v8.i18.663]
Corresponding Author of This Article
Jin Kan Sai, MD, Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. jinkans@juntendo.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
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World J Gastrointest Endosc. Oct 16, 2016; 8(18): 663-668 Published online Oct 16, 2016. doi: 10.4253/wjge.v8.i18.663
Prior minimal endoscopic sphincterotomy to prevent pancreatitis related to endoscopic balloon sphincteroplasty
Ryo Kanazawa, Jin Kan Sai, Tomoyasu Ito, Hiroko Miura, Shigeto Ishii, Hiroaki Saito, Ko Tomishima, Ryo Shimizu, Koki Sato, Manabu Hayashi, Sumio Watanabe, Shuichiro Shiina
Ryo Kanazawa, Jin Kan Sai, Tomoyasu Ito, Hiroko Miura, Shigeto Ishii, Hiroaki Saito, Ko Tomishima, Ryo Shimizu, Koki Sato, Manabu Hayashi, Sumio Watanabe, Shuichiro Shiina, Department of Gastroenterology, Juntendo University School of Medicine, Tokyo 113-8421, Japan
Author contributions: Kanazawa R and Sai JK contributed equally to this work; Kanazawa R collected and analyzed the data, and drafted the manuscript; Sai JK provided analytical oversightand designed and supervised the study; Watanabe S and Shiina S revised the manuscript for the important intellectual content; Ito T, Miura H, Ishii S, Saito H, Tomishima K, Shimizu R, Sato K and Hayashi M supported collecting the data; all authors have read and approved the final version to be published.
Institutional review board statement: This study was approved by the Institutional Review Board of Juntendo University.
Clinical trial registration statement: In the study period (October 2010 - March 2014), clinical trial registration was not required for our prospective study.
Informed consent statement: Written informed consent for the procedures and treatment was obtained from patients or their next of kin in accordance with normal clinical practice.
Conflict-of-interest statement: No conflict of interests.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at jinkans@juntendo.ac.jp. Participants gave informed consent was not obtained but the presented data are anonymized and risk of identification is low.
Correspondence to: Jin Kan Sai, MD, Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. jinkans@juntendo.ac.jp
Telephone: +81-3-58021061 Fax: +81-3-56845960
Received: February 2, 2016 Peer-review started: February 9, 2016 First decision: March 23, 2016 Revised: July 18, 2016 Accepted: August 6, 2016 Article in press: August 8, 2016 Published online: October 16, 2016 Processing time: 254 Days and 2.7 Hours
Core Tip
Core tip: We evaluated the efficacy of prior minimal endoscopic sphincterotomy (EST) to prevent pancreatitis related to endoscopic balloon sphincteroplasty (EBS). One hundred and five patients with bile duct stones < 8 mm were subjected to minimal EST (up to one-third of the size the papilla) plus 8 mm EBS (EST-EBS group). The incidence of pancreatitis and the difference in serum amylase level after the procedure were examined and compared with those associated with 8-mm EBS alone in 32 patients of historical control (control group). The difference in serum amylase level after the procedure in the EST-EBS group was significantly lower than that observed in the control group (P < 0.001). The incidence of post-procedure pancreatitis was 0% (0/105) in the EST-EBS group and 15.6% (5/32) in the control group (P < 0.001).
