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World J Gastrointest Endosc. May 16, 2013; 5(5): 226-230
Published online May 16, 2013. doi: 10.4253/wjge.v5.i5.226
Published online May 16, 2013. doi: 10.4253/wjge.v5.i5.226
Colonoscopy in rats: An endoscopic, histological and tomographic study
Ramon Bartolí, Vicente Lorenzo-Zúñiga, Gemma Ódena, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 08916 Badalona, Spain
Jaume Boix, Vicente Moreno de Vega, Endoscopy Unit, Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain
Napoleón D De la Ossa, Department of Pathology, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain
Vicente Lorenzo-Zúñiga, Endoscopy Unit, Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916 Badalona, Spain
Author contributions: Bartoli R and Òdena G performed the tomographic study; Boix J, de Vega VM and Lorenzo-Zúñiga V performed the endoscopic study; De la Ossa ND provided the histological assessment; Bartoli R and Lorenzo-Zúñiga V were also involved in editing the manuscript, co-ordinated the study and wrote the manuscript.
Supported by Spanish Carlos III Institute Project Grant, No. PI10/00132
Correspondence to: Vicente Lorenzo-Zúñiga, MD, PhD, Endoscopy Unit, Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916 Badalona, Spain. vlorenzo.germanstrias@gencat.cat
Telephone: +34-93-4978866 Fax: +34-93-4978946
Received: June 27, 2012
Revised: March 5, 2013
Accepted: March 15, 2013
Published online: May 16, 2013
Processing time: 242 Days and 21.9 Hours
Revised: March 5, 2013
Accepted: March 15, 2013
Published online: May 16, 2013
Processing time: 242 Days and 21.9 Hours
Core Tip
Core tip: There is a need for a solid colonoscopy animal model, complemented with digital radiology. Our subdivision of the rat colon constitutes a simplification of subdivisions presented by others who have emphasized the theoretical anatomical data. Our proposed subdivision of the colon is practical and justified by the importance of endoscopic access and the thickness of various portions of the colon wall. This study identified that the muscular layer was thinner in the proximal left colon. These findings are important for deciding when to perform endoscopic resections or when to induce perforations to apply endoscopic treatments.