Endoscopic submucosal dissection for malignant melanoma and esophageal squamous cell carcinoma: A case report and review of literature

doi:10.4253/wjge.122701

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Endosc. Aug 16, 2026; 18(8): 122701
Published online Aug 16, 2026. doi: 10.4253/wjge.122701

Endoscopic submucosal dissection for malignant melanoma and esophageal squamous cell carcinoma: A case report and review of literature

Yan-Yan Hao, Jin-Feng Cui, Chen-Guang Ji, Li Liu, Kai-Ge Yin

Yan-Yan Hao, Chen-Guang Ji, Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China

Jin-Feng Cui, Department of Pathology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China

Li Liu, Kai-Ge Yin, Endoscopy Center, Luquan Campus, The Second Hospital of Hebei Medical University, Shijiazhuang 050200, Hebei Province, China

Co-corresponding authors: Li Liu and Kai-Ge Yin.

Author contributions: Liu L and Yin KG contribute equally to this study as co-corresponding authors; Hao YY drafted the article and conducted subsequent revisions; Yin KG performed the surgery; Cui JF presented images of the lesion before and following immunohistochemical staining; Ji CG offered valuable suggestions for improving the manuscript; Liu L contributed to critically revising the manuscript for important intellectual content; and all authors gave final approval for the version to be submitted.

AI contribution statement: The authors declare that no artificial intelligence (AI) tools or large language models were used in the conception, drafting, revision, or any other stage of this manuscript. The authors assume full responsibility and accountability for the integrity, accuracy, and originality of the submitted work.

Supported by Hebei Provincial Department of Finance, China, Grant No. ZF2024050.

Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any associated images.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: Li Liu, MD, PhD, Endoscopy Center, Luquan Campus, The Second Hospital of Hebei Medical University, No. 501 Huai'an West Road, Luquan District, Shijiazhuang 050200, Hebei Province, China. loraliu@163.com

Received: April 27, 2026
Revised: June 28, 2026
Accepted: July 30, 2026
Published online: August 16, 2026
Processing time: 107 Days and 13.5 Hours

Core Tip

Core Tip: Primary malignant melanoma of the esophagus (PMME) and squamous cell carcinoma (SCC) are rarely synchronous. We report a unique collision tumor comprising PMME with SCC in a 60-year-old male. Endoscopic submucosal dissection (ESD) achieved R0 resection; postoperative stricture was managed with a balloon dilator. No recurrence was observed within the 19-month follow-up. This case suggests that ESD is a feasible treatment modality for incidental microscopic melanoma foci. However, radical surgery remains the standard therapy, and intensive surveillance is mandatory.