Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Endosc. Jul 16, 2026; 18(7): 121964
Published online Jul 16, 2026. doi: 10.4253/wjge.121964
Published online Jul 16, 2026. doi: 10.4253/wjge.121964
Ankaferd blood stopper application in gastrointestinal bleeding: An updated narrative review
Furkan M Çakmak, Abdurrahman Özkan, Cem Simsek, Department of Gastroenterology and Endoscopy, Hacettepe University Faculty of Medicine, Ankara 06230, Altindag, Türkiye
Hakan Aydınlı, Faculty of Medicine, Hacettepe University Faculty of Medicine, Ankara 06230, Altindag, Türkiye
Ibrahim C Haznedaroglu, Department of Hematology, Hacettepe University, Faculty of Me
Co-first authors: Furkan M Çakmak and Hakan Aydınlı.
Author contributions: Çakmak FM and Aydınlı H performed the literature review and drafted the manuscript; they contributed equally to this article and are the co-first authors of this manuscript; Ozkan A contributed to data interpretation and manuscript revision; Haznedaroglu IC contributed to study design and supervision; Simsek C designed the study; all authors reviewed and approved the final version of the manuscript.
AI contribution statement: During the preparation of this manuscript, the authors utilized Gemini 3 Pro and ChatGPT-5.2 Pro for language refinement, stylistic editing and editorial assistance to improve readability and clarity of the text. The authors declare that no generative artificial intelligence was used for creation, analysis or conclusions. All AI-assisted outputs were rigorously reviewed, verified and validated by the authors who maintain full accountability for the accuracy, technical integrity and originality of the final work.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Corresponding author: Cem Simsek, MD, PhD, Associate Professor, Department of Gastro
Received: April 7, 2026
Revised: May 3, 2026
Accepted: July 2, 2026
Published online: July 16, 2026
Processing time: 101 Days and 17 Hours
Revised: May 3, 2026
Accepted: July 2, 2026
Published online: July 16, 2026
Processing time: 101 Days and 17 Hours
Core Tip
Core Tip: Ankaferd blood stopper (ABS) represents a novel non-coagulation-dependent hemostatic approach that may expand the therapeutic options for gastrointestinal bleeding. Unlike conventional endoscopic methods, ABS acts rapidly and can be applied easily, making it particularly attractive in challenging or inaccessible bleeding sites. Its potential role as a bridging or rescue therapy in refractory bleeding highlights its clinical relevance. Although current evidence is limited, ABS may offer a practical adjunct in selected cases, warranting further investigation in well-designed prospective studies.