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World J Gastrointest Endosc. Jun 16, 2026; 18(6): 119473
Published online Jun 16, 2026. doi: 10.4253/wjge.v18.i6.119473
Published online Jun 16, 2026. doi: 10.4253/wjge.v18.i6.119473
Polyposis in Lynch syndrome: A retrospective study
Nadeen Sarsour, Eve Karloski, Beth Dudley, Randall E Brand, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, United States
Shikhar Uttam, Department of Computational and Systems Biology, University of Pittsburgh and UPMC Hillman Cancer Center, Pittsburgh, PA 15213, United States
Brenda Diergaarde, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, and UPMC Hillman Cancer Center, Pittsburgh, PA 15213, United States
Author contributions: Sarsour N contributed to drafting of the article; Uttam S contributed to interpretation of the data; Sarsour N, Dudley B, Karloski E, Uttam S, Diergaarde B, and Brand R contributed to critical revision of the article for important intellectual content, final approval of the article; Sarsour N, Dudley B, Karloski E, and Brand R contributed to conception and design; Sarsour N, Diergaarde B, and Brand R contributed to analysis and interpretation of the data.
Institutional review board statement: Hereditary Colorectal and Associated Tumor Study, the study was reviewed and approved by the Institutional Review Board of University of Pittsburgh, No. MOD19050027-026.
Informed consent statement: Obtained informed consent approved by institutional review board.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at brandre@upmc.edu.
Corresponding author: Randall E Brand, MD, Department of Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, United States. brandre@upmc.edu
Received: January 28, 2026
Revised: March 11, 2026
Accepted: May 8, 2026
Published online: June 16, 2026
Processing time: 133 Days and 5.8 Hours
Revised: March 11, 2026
Accepted: May 8, 2026
Published online: June 16, 2026
Processing time: 133 Days and 5.8 Hours
Core Tip
Core Tip: The purpose of this study was to describe and investigate polyposis (≥ 10 lifetime adenomas) in patients with a diagnosis of Lynch syndrome (LS). Previously known as hereditary nonpolyposis syndrome, more data have emerged describing polyposis in these patients. We used a registry of patients with LS at our institution to find possible associations and commonalities among patients who had ≥ 10 lifetime adenomas to help determine which of these high-risk patients may be at higher risk for developing adenomas. We discovered that patients with polyposis more often had pathogenic variants in the MSH2 and MSH6 genes.