Expanding the therapeutic spectrum for duodenal adenomas: Cryoballoon ablation

doi:10.4253/wjge.v18.i6.117354

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Endosc. Jun 16, 2026; 18(6): 117354
Published online Jun 16, 2026. doi: 10.4253/wjge.v18.i6.117354

Expanding the therapeutic spectrum for duodenal adenomas: Cryoballoon ablation

Jun Hwan Yoo, Jun-Young Seo

Jun-Young Seo, Jun Hwan Yoo, Division of Gastroenterology and Hepatology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Gyeonggi-do 463-712, South Korea

Author contributions: Seo JY and Yoo JH were involved in drafting the manuscript and/or critically revising it for important intellectual content. All authors have approved the final version of the manuscript for publication.

AI contribution statement: ChatGPT was used only for language polishing and editorial assistance. No AI tool was used for study design, data collection, data analysis, interpretation of the results, or generation of scientific conclusions. In addition, no images, figures, tables, or primary data were generated by AI. All authors reviewed and verified the final manuscript and take full responsibility for its content.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Jun Hwan Yoo, MD, PhD, Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Gyeonggi-do 463-712, South Korea. jhyoo@cha.ac.kr

Received: December 5, 2025
Revised: February 17, 2026
Accepted: April 10, 2026
Published online: June 16, 2026
Processing time: 187 Days and 7.5 Hours

Core Tip

Core Tip: Cryoballoon ablation provides a selective, depth-limited injury that preserves the collagen matrix, making it a promising option for duodenal adenomas when conventional resection is unsafe. This technique is particularly useful for flat, fibrotic, or recurrent lesions for which endoscopic mucosal resection is difficult or hazardous and in which thermal ablation carries an increased perforation risk. This modality may fill an important therapeutic niche for patients with anatomically challenging or high-risk adenomas.