Amalou K, Benboudiaf N, Medkour MT, Belghanem F, Chetroub H, Rekab R, Belloula A, Bouaouina F, Saidani K. Lactated Ringer’s solution in combination with indomethacin for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A prospective, randomized trial. World J Gastrointest Endosc 2026; 18(1): 113788 [DOI: 10.4253/wjge.v18.i1.113788]
Corresponding Author of This Article
Khellaf Amalou, PhD, Assistant Professor, Department of Gastroenterology, Mohamed Seghir Nekkache, Kouba 246, Algiers 16000, Algeria. amalou_kh@yahoo.fr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Randomized Controlled Trial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 16, 2026 (publication date) through Jan 16, 2026
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Publication Name
World Journal of Gastrointestinal Endoscopy
ISSN
1948-5190
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Amalou K, Benboudiaf N, Medkour MT, Belghanem F, Chetroub H, Rekab R, Belloula A, Bouaouina F, Saidani K. Lactated Ringer’s solution in combination with indomethacin for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A prospective, randomized trial. World J Gastrointest Endosc 2026; 18(1): 113788 [DOI: 10.4253/wjge.v18.i1.113788]
World J Gastrointest Endosc. Jan 16, 2026; 18(1): 113788 Published online Jan 16, 2026. doi: 10.4253/wjge.v18.i1.113788
Lactated Ringer’s solution in combination with indomethacin for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A prospective, randomized trial
Khellaf Amalou, Nadjib Benboudiaf, Mohamed Tahar Medkour, Farid Belghanem, Hana Chetroub, Ryma Rekab, Ahlem Belloula, Fateh Bouaouina, Khadidja Saidani, Department of Gastroenterology, Mohamed Seghir Nekkache, Algiers 16000, Algeria
Author contributions: Amalou K took responsibility in necessary literature review for the study, writing of the whole of the article and review it before submission scientifically besides spelling and grammar; Benboudiaf N, Medkour MT, Belghanem F, Chetroub H, and Bouaouina F analyzed the data and wrote the manuscript; Rekab R, Belloula A, and Saidani K reviewed the article before submission; all authors have and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board.
Clinical trial registration statement: This trial was registered online at the Pan African Clinical Trials Registry (https://pactr.samrc.ac.za/) before the enrollment of any patients, No. PACTR202201712208274.
Informed consent statement: All participants provided informed consent.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Khellaf Amalou, PhD, Assistant Professor, Department of Gastroenterology, Mohamed Seghir Nekkache, Kouba 246, Algiers 16000, Algeria. amalou_kh@yahoo.fr
Received: September 4, 2025 Revised: October 29, 2025 Accepted: December 4, 2025 Published online: January 16, 2026 Processing time: 133 Days and 9.8 Hours
Core Tip
Core Tip: Endoscopic retrograde cholangiopancreatography is an important technique for the diagnosis and treatment of pancreaticobiliary disorders. Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is the most prevalent complication relating to endoscopic retrograde cholangiopancreatography. Rectal nonsteroidal anti-inflammatory drugs and prophylactic pancreatic stent insertion remain advised for its prevention. The administration of lactated Ringer’s solution (LR) plays an important part in preventing pancreatic necrosis and organ failure by sustaining steady pancreatic microcirculation. This randomized, double-blind, controlled study showed that the infusion of LR combined with rectal indomethacin (IND) may decrease the occurrence of PEP and post-procedure readmission in high-risk patients, compared to LR or IND administered separately.
