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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Sep 16, 2025; 17(9): 110850
Published online Sep 16, 2025. doi: 10.4253/wjge.v17.i9.110850
Published online Sep 16, 2025. doi: 10.4253/wjge.v17.i9.110850
Gyrus-like endoscopic changes in autoimmune gastritis with past Helicobacter pylori infection: Two case reports and review of literature
Chuan-Chuan Tan, Xue-Li Shangguan, Fang-Fang Deng, Yang-Peng Wu, Department of Gastroenterology, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China
Xiao-Ming Lei, School of Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China
Guo-Min Zhang, School of Integrated Chinese and Western Medicine, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China
Author contributions: Tan CC contributed to manuscript writing and editing, conceptualization, investigation, and methodology; Shangguan XL contributed to manuscript writing and editing, and investigation; Lei XM contributed to manuscript review and editing, methodology and conceptualization; Deng FF and Wu YP contributed to manuscript editing and data collection; Zhang GM contributed to manuscript review and editing, and supervision; all authors have read and approved the final manuscript.
Supported by the General Program of the National Natural Science Foundation of China, No. 81973920.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Min Zhang, PhD, Professor, School of Integrated Chinese and Western Medicine, Hunan University of Traditional Chinese Medicine, No. 300 Xueshi Road, Changsha 410208, Hunan Province, China. 003334@hnucm.edu.cn
Received: June 17, 2025
Revised: July 11, 2025
Accepted: August 19, 2025
Published online: September 16, 2025
Processing time: 87 Days and 15.5 Hours
Revised: July 11, 2025
Accepted: August 19, 2025
Published online: September 16, 2025
Processing time: 87 Days and 15.5 Hours
Core Tip
Core Tip: We present two patients diagnosed with autoimmune gastritis (AIG) after past Helicobacter pylori (H. pylori) infection. In both, the reverse atrophy characteristic of AIG was absent. We identified gyrus-like changes, characterized by mildly elevated mucosa between deep fissures, as a novel endoscopic feature. Histology confirmed the early pathology of AIG in these areas. This previously unrecognized endoscopic pattern offers a valuable clue of detecting AIG in patients with past H. pylori infection that may facilitate the early recognition and management of this condition.