Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Jun 16, 2025; 17(6): 107142
Published online Jun 16, 2025. doi: 10.4253/wjge.v17.i6.107142
Advancing hemostasis: A meta-analysis of novel vs conventional endoscopic therapies for non variceal upper gastrointestinal bleeding
Shivangini Duggal, Ishana Kalra, Keisha Kalra, Vicky Bhagat
Shivangini Duggal, Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, United States
Ishana Kalra, Keisha Kalra, University of Michigan, University of Michigan, Michigan City, IN 48104, United States
Vicky Bhagat, Department of Gastroenterology, Atlantic Health System, Bayonne, NJ 07002, United States
Author contributions: Duggal S, Kalra I, Kalra K designed this paper; Duggal S, Kalra I, Kalra K investigation and review of relevant data and articles; Duggal S analysis data; Duggal S, Kalra I, Kalra K written the original draft; Bhagat V review and editing this paper. All authors discussed the findings described in the case and approved the final manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
PRISMA 2009 Checklist statement: The present systematic review and network meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the PRISMA Network Meta-analyses Extension Statement. A literature search was conducted on Cochrane, MEDLINE, PubMed and Scopus libraries for all articles published up to October 2024. Only English language articles were included.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shivangini Duggal, MD, Internal Medicine, Texas Tech University Health Sciences Center, 5001 El Paso Dr, El Paso, TX 79905, United States. sduggal@ttuhsc.edu
Received: March 17, 2025
Revised: April 7, 2025
Accepted: May 8, 2025
Published online: June 16, 2025
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Core Tip

Core Tip: This systematic review and network meta-analysis compares the efficacy of novel hemostatic interventions-over-the-scope clips (OTSC) and hemostatic powders (HP)-to conventional endoscopic therapy computed tomography (CT) for non variceal upper gastrointestinal bleeding (NVUGIB). OTSC demonstrated superior efficacy in reducing 30-day and short-term rebleeding rates, ranking as the most effective intervention. HP provided a moderate benefit but did not surpass CT. These findings support OTSC as a first-line treatment for high-risk NVUGIB, while HP remains a viable adjunct.