Krishnan A. Endoscopic intervention in hematologic malignancy patients with severe thrombocytopenia: Methodological concerns, clinical implications, and future research directions. World J Gastrointest Endosc 2025; 17(4): 105630 [DOI: 10.4253/wjge.v17.i4.105630]
Corresponding Author of This Article
Arunkumar Krishnan, MD, Associate Professor, Senior Researcher, Department of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70100, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Apr 16, 2025; 17(4): 105630 Published online Apr 16, 2025. doi: 10.4253/wjge.v17.i4.105630
Endoscopic intervention in hematologic malignancy patients with severe thrombocytopenia: Methodological concerns, clinical implications, and future research directions
Arunkumar Krishnan
Arunkumar Krishnan, Department of Supportive Oncology, Atrium Health Levine Cancer, Charlotte, NC 28204, United States
Author contributions: Krishnan A contributed to the concept of the study, drafted the manuscript, performed the review and editing, and critically revised and finalized the manuscript for important intellectual content.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arunkumar Krishnan, MD, Associate Professor, Senior Researcher, Department of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70100, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com
Received: February 2, 2025 Revised: March 16, 2025 Accepted: April 2, 2025 Published online: April 16, 2025 Processing time: 73 Days and 13 Hours
Core Tip
Core Tip: Endoscopic intervention for gastrointestinal bleeding in patients with severe thrombocytopenia is debated due to the lack of standardized platelet thresholds and procedural risks. A recent study by Alhumayyd et al highlighted these challenges but was limited by small sample sizes, retrospective design, and inadequate adjustment for confounders. Key factors like hemodynamic stability, hematologic malignancy severity, and platelet function assessments were insufficiently addressed. Variations in endoscopic timing and hemostasis techniques further complicate results. Prospective, multicenter studies incorporating platelet function assays and standardized protocols are essential to improve gastrointestinal bleeding management in thrombocytopenic patients.
