Alali AA, Ali N, Hashim A, Alhaqqan D, Aljasser W, Almudaires A, Bastaki S, Alhashmi A, Altaleb A. Feasibility and safety of endoscopic ultrasound-guided liver biopsy to diagnose parenchymal liver disease: A multi-centre retrospective cohort study. World J Gastrointest Endosc 2025; 17(12): 112485 [DOI: 10.4253/wjge.v17.i12.112485]
Corresponding Author of This Article
Ali A Alali, Assistant Professor, Department of Medicine, Faculty of Medicine, Kuwait University, Block 4, Jabriyah 13110, Kuwait. alali.a@ku.edu.kw
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 16, 2025 (publication date) through Dec 19, 2025
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Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Endoscopy
ISSN
1948-5190
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Alali AA, Ali N, Hashim A, Alhaqqan D, Aljasser W, Almudaires A, Bastaki S, Alhashmi A, Altaleb A. Feasibility and safety of endoscopic ultrasound-guided liver biopsy to diagnose parenchymal liver disease: A multi-centre retrospective cohort study. World J Gastrointest Endosc 2025; 17(12): 112485 [DOI: 10.4253/wjge.v17.i12.112485]
World J Gastrointest Endosc. Dec 16, 2025; 17(12): 112485 Published online Dec 16, 2025. doi: 10.4253/wjge.v17.i12.112485
Feasibility and safety of endoscopic ultrasound-guided liver biopsy to diagnose parenchymal liver disease: A multi-centre retrospective cohort study
Ali A Alali, Nargess Ali, Ahmad Hashim, Dalal Alhaqqan, Wadha Aljasser, Abdulaziz Almudaires, Shahad Bastaki, Ahmad Alhashmi, Ahmad Altaleb
Ali A Alali, Nargess Ali, Shahad Bastaki, Ahmad Alhashmi, Department of Medicine, Faculty of Medicine, Kuwait University, Jabriyah 13110, Kuwait
Ali A Alali, Wadha Aljasser, Abdulaziz Almudaires, Thunayan Alghanim Gastroenterology Center, Amiri Hospital, Sharq 15300, Kuwait
Ahmad Hashim, Dalal Alhaqqan, Haya Alhabeeb Gastroenterology Center, Mubarak Alkabeer Hospital, Jabriyah 32052, Kuwait
Ahmad Altaleb, Department of Pathology, Mubarak Alkabeer Hospital, Jabriyah 32052, Kuwait
Author contributions: Alali AA, Ali N, Hashim A, Alhaqqan D, Aljasser W, Almudaires A, and Bastaki S collected the data and performed data analysis; Alali AA, Alhashmi A, and Altaleb A wrote the manuscript, reviewed the data, and prepared the tables. All authors approved the final version of the manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Ministry of Health of Kuwait, No. 2023/2430.
Informed consent statement: Written informed consent was obtained from the patients before EUS-LB.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: All data that support the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ali A Alali, Assistant Professor, Department of Medicine, Faculty of Medicine, Kuwait University, Block 4, Jabriyah 13110, Kuwait. alali.a@ku.edu.kw
Received: July 29, 2025 Revised: September 8, 2025 Accepted: October 21, 2025 Published online: December 16, 2025 Processing time: 140 Days and 19.8 Hours
Core Tip
Core Tip: Endoscopic ultrasound-guided liver biopsy (EUS-LB) has recently been introduced as an endoscopic method for obtaining liver biopsy in patients with suspected parenchymal liver disease. However, the efficacy and safety of this approach remain unclear. Furthermore, some uncertainty exists in the most appropriate needle size and suction technique to achieve an optimal histological specimen. This multicenter retrospective study found a high diagnostic yield for EUS-LB with a low rate of serious adverse events. In addition, the use of a 19-gauge fine needle biopsy needle, the wet-heparin suction technique, and performing ≤ 2 passes was associated with improved quality of the specimen obtained without increasing the risk of adverse events.
