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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Dec 16, 2025; 17(12): 111872
Published online Dec 16, 2025. doi: 10.4253/wjge.v17.i12.111872
Published online Dec 16, 2025. doi: 10.4253/wjge.v17.i12.111872
Initial treatment approaches for nodular gastric antral vascular ectasia: A comparison of endoscopic band ligation and thermal therapies
John Andrew Cooper, Elizabeth Statham, Tinsley Harrison Internal Medicine Residency Program, The University of Alabama at Birmingham, Birmingham, AL 35294, United States
Ada Holyfield, Department of Gastroenterology, The University of Alabama at Birmingham, Birmingham, AL 35294, United States
Mohamed G Shoreibah, Shajan Peter, Department of Gastroenterology and Hepatology, The University of Alabama at Birmingham, Birmingham, AL 35294, United States
Author contributions: Cooper JA, Statham EG, Holyfield A, Shoreibah MG, and Peter S participated in the conception and design of the study and were involved in the acquisition, or interpretation of data; John C wrote the manuscript; Cooper JA, Statham EG, Holyfield A, Shoreibah MG, and Peter S critically reviewed and provided final approval of the manuscript and were responsible for the decision to submit the manuscript for publication.
Institutional review board statement: This investigation was approved by the Institutional Ethics Committee of The University of Alabama at Birmingham.
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data supporting the findings of this retrospective study are derived from medical records and are not publicly available due to privacy concerns. However, de-identified data may be made available upon reasonable request to the corresponding author, subject to approval by the University of Alabama at Birmingham, IRB. Access will be granted in compliance with applicable data protection regulations and institutional guidelines.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: John Andrew Cooper, MD, Tinsley Harrison Internal Medicine Residency Program, The University of Alabama at Birmingham, 1808 7th Avenue South, Birmingham, AL 35294, United States. jacooper4196@gmail.com
Received: July 11, 2025
Revised: August 18, 2025
Accepted: November 7, 2025
Published online: December 16, 2025
Processing time: 158 Days and 9.4 Hours
Revised: August 18, 2025
Accepted: November 7, 2025
Published online: December 16, 2025
Processing time: 158 Days and 9.4 Hours
Core Tip
Core Tip: Nodular gastric antral vascular ectasia (GAVE) is a rare and treatment-resistant subtype of GAVE with limited data guiding optimal therapy. This retrospective study compares endoscopic band ligation (EBL) and endoscopic thermal therapy, including argon plasma coagulation and radiofrequency ablation, as initial treatments for nodular GAVE. Patients initially treated with EBL achieved significantly higher clinical remission rates, required fewer procedures, and had shorter treatment intervals. These findings suggest that EBL may be a more effective first-line treatment for nodular GAVE, offering improved outcomes and reduced treatment burden compared to traditional thermal modalities.