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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Oct 16, 2025; 17(10): 107482
Published online Oct 16, 2025. doi: 10.4253/wjge.v17.i10.107482
Published online Oct 16, 2025. doi: 10.4253/wjge.v17.i10.107482
How to distinguish pancreatic tumors and assess the necessity for biopsy
Ming-Sheng Chien, Ching-Chung Lin, Jian-Han Lai, Department of Internal Medicine, MacKay Memorial Hospital, Taipei 104217, Taiwan
Ching-Chung Lin, Jian-Han Lai, Faculty of Medicine, MacKay Medical College, New Taipei 252005, Taiwan
Jian-Han Lai, Department of Nursing, MacKay Medicine Nursing and Management, Taipei 11260, Taiwan
Author contributions: Chien MS and Lin CC conducted the literature review, and drafted the original manuscript; Lai JH conceptualized and designed the study, supervised, and made critical revisions; and all authors prepared the draft and approved the submitted version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Han Lai, MD, Department of Internal Medicine, MacKay Memorial Hospital, No. 92 Section 2, Chung-Shan North Road, Taipei 104217, Taiwan.
Received: March 25, 2025
Revised: May 26, 2025
Accepted: September 3, 2025
Published online: October 16, 2025
Processing time: 205 Days and 22.7 Hours
Revised: May 26, 2025
Accepted: September 3, 2025
Published online: October 16, 2025
Processing time: 205 Days and 22.7 Hours
Core Tip
Core Tip: This article highlights the endoscopic ultrasonography, assisted by contrast enhanced sonography and elastography, offers superior accuracy in detecting and characterizing pancreatic tumors. By assessing morphology, vascularity, and tissue stiffness, it differentiates malignant from benign processes and identifies high-risk cystic lesions. Endoscopic ultrasonography-guided fine needle biopsy enables histological and molecular diagnosis, including next generation sequencing for actionable mutations, guiding surgical decisions, neoadjuvant therapy, and targeted treatments. This integrated approach optimizes pancreatic cancer detection, staging, and personalized management while avoiding unnecessary interventions.