Retrospective Cohort Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. May 16, 2023; 15(5): 386-396
Published online May 16, 2023. doi: 10.4253/wjge.v15.i5.386
Expanding endoscopic boundaries: Endoscopic resection of large appendiceal orifice polyps with endoscopic mucosal resection and endoscopic submucosal dissection
Ankur P Patel, Mai A Khalaf, Margarita Riojas-Barrett, Tara Keihanian, Mohamed O Othman
Ankur P Patel, Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030, United States
Mai A Khalaf, Department of Tropical Medicine, Tanta University, Tanta 31527, Egypt
Margarita Riojas-Barrett, Tara Keihanian, Mohamed O Othman, Department of Gastroenterology, Baylor College of Medicine, Houston, TX 77030, United States
Author contributions: Patel AP collected the data, analyzed and interpreted the data, drafted the manuscript, and performed statistical analysis; Khalaf MA and Riojas-Barrett M collected the data; Keihanian T collected the data, analyzed and interpreted the data, performed statistical analysis, and revised the manuscript; Othman MO created the study design, revised the manuscript, and supervised the study; all authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Baylor College of Medicine Institutional Review Board (Approval Number: H-50836).
Informed consent statement: A waiver of consent was obtained from the Baylor College of Medicine Institutional Review Board.
Conflict-of-interest statement: Tara Keihanian has received fees for serving as a consultant for Lumendi and Neptune Medical. Mohamed O Othman has received fees for serving as a consultant for Olympus America, Abbvie, Boston Scientific Corporation, Lumendi, Apollo, Conmed, and Medtronic. Mohamed O Othman has received research funding from Olympus America, Abbvie, Boston Scientific Corporation, and US Biotest.
Data sharing statement: The dataset is available from the corresponding author at mohamed.othman@bcm.edu. Consent was not obtained but the presented data are anonymized and the risk of identification is low.
STROBE statement: The authors have read the STROBE Statement - checklist of items, and the manuscript was prepared and revised accordingly.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohamed O Othman, MD, Chief Physician, Professor, Department of Gastroenterology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, United States. mohamed.othman@bcm.edu
Received: February 17, 2023
Peer-review started: February 17, 2023
First decision: March 28, 2023
Revised: April 10, 2023
Accepted: April 18, 2023
Article in press: April 18, 2023
Published online: May 16, 2023
Processing time: 88 Days and 7 Hours
Core Tip

Core Tip: In this study, we evaluated endoscopic mucosal resection, endoscopic submucosal dissection, and hybrid procedures for the resection of large appendiceal polyps. Compared to previously published studies, we noticed a higher en bloc resection rate and R0 resection rate in our study, despite a larger polyp size. Our data supported these procedures as safe and efficacious for the management of large polyps in a challenging location such as the appendiceal orifice, with minimal to no adverse events.