Sehgal A, Aggarwal S, Mandaliya R, Loughney T, Mattar MC. Improving sessile serrated adenoma detection rates with high definition colonoscopy: A retrospective study. World J Gastrointest Endosc 2022; 14(4): 226-234 [PMID: 35634484 DOI: 10.4253/wjge.v14.i4.226]
Corresponding Author of This Article
Abhinav Sehgal, BSc, Academic Research, Department of Gastroenterology, Georgetown University School of Medicine, 3800 Reservoir Road NW, Washington, DC 20007, United States. as4426@georgetown.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Apr 16, 2022; 14(4): 226-234 Published online Apr 16, 2022. doi: 10.4253/wjge.v14.i4.226
Improving sessile serrated adenoma detection rates with high definition colonoscopy: A retrospective study
Abhinav Sehgal, Soorya Aggarwal, Rohan Mandaliya, Thomas Loughney, Mark C Mattar
Abhinav Sehgal, Department of Gastroenterology, Georgetown University School of Medicine, Washington, DC 20007, United States
Soorya Aggarwal, Rohan Mandaliya, Thomas Loughney, Mark C Mattar, Division of Gastroenterology, MedStar Georgetown University Hospital, Washington, DC 20007, United States
Author contributions: Sehgal A, Aggarwal S, Mandaliya R, Loughney TM, and Mattar MC designed the research study; Sehgal A and Aggarwal S performed the research; Sehgal A collected and analyzed the data; Sehgal A and Aggarwal S wrote the manuscript; All authors have read and approved the final manuscript.
Institutional review board statement: As our retrospective study qualified as a quality improvement project, our institution did not require IRB approval for our study.
Informed consent statement: As our study was a quality-improvement study with retrospective chart review, informed consent was not necessary at our institution. Any and all details that might disclose the identity of the subjects included in our study were omitted.
Conflict-of-interest statement: The authors declare no conflict of interests that are related to the work submitted for consideration of publication.
Data sharing statement: Dataset available from the corresponding author at as4426@georgetown.edu. Consent was not obtained but the presented data are anonymized and risk of identification is low.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abhinav Sehgal, BSc, Academic Research, Department of Gastroenterology, Georgetown University School of Medicine, 3800 Reservoir Road NW, Washington, DC 20007, United States. as4426@georgetown.edu
Received: July 14, 2021 Peer-review started: July 14, 2021 First decision: September 5, 2021 Revised: September 13, 2021 Accepted: January 25, 2022 Article in press: January 25, 2022 Published online: April 16, 2022 Processing time: 267 Days and 10.8 Hours
Core Tip
Core Tip: Sessile serrated adenomas (SSA) have become increasingly recognized as important premalignant lesions that are difficult to detect during colonoscopy due to similarity in appearance to surrounding colonic mucosa. We performed a retrospective study to evaluate the impact of high definition (HD) colonoscopy compared to standard definition colonoscopy on SSA detection rate (SSADR) during screening colonoscopy. Our study found a statistically significant benefit to SSADR with HD colonoscopy that also met benchmark detection rates. To our knowledge, this study is the first to show the utility of HD colonoscopy for SSADR in average-risk patients, thereby demonstrating it as an important tool for routine colorectal cancer screening. In the absence of a strong clinical guideline to obligate the use of HD colonoscopy, the benefit demonstrated to SSADR by HD colonoscopy in our study may help strengthen the evidence to recommend its use in all settings.
