Passi M, Rahman F, Gurram S, Kumar S, Koh C. Identifying who best tolerates moderate sedation: Results from a national database of gastrointestinal endoscopic outcomes. World J Gastrointest Endosc 2021; 13(4): 97-110 [PMID: 33959232 DOI: 10.4253/wjge.v13.i4.97]
Corresponding Author of This Article
Monica Passi, MD, Academic Fellow, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive Clinical Research Center, 5-2740, Bethesda, MD 20892, United States. mpassi305@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Apr 16, 2021; 13(4): 97-110 Published online Apr 16, 2021. doi: 10.4253/wjge.v13.i4.97
Identifying who best tolerates moderate sedation: Results from a national database of gastrointestinal endoscopic outcomes
Monica Passi, Farial Rahman, Sandeep Gurram, Sheila Kumar, Christopher Koh
Monica Passi, Sheila Kumar, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, United States
Farial Rahman, Christopher Koh, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, United States
Sandeep Gurram, Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States
Author contributions: Koh C is the guarantor of this article; Passi M, Rahman F and Koh C designed the study and were involved in devising the study concept; Passi M, Kumar S and Gurram S were involved in the acquisition of the study data; Passi M and Rahman F were involved in the statistical analysis and interpretation of study results; Passi M, Rahman F, Koh C, and Gurram S were involved in the drafting and revision of the manuscript; all authors have read and approve the final manuscript.
Institutional review board statement: This study is a retrospective analysis of a publicly available, de-identified data repository (Clinical Outcomes Research Initiative National Endoscopic Database) and therefore is IRB-exempt.
Informed consent statement: This study is a retrospective analysis of a publicly available, de-identified data repository. Informed consent is not indicated.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Monica Passi, MD, Academic Fellow, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive Clinical Research Center, 5-2740, Bethesda, MD 20892, United States. mpassi305@gmail.com
Received: January 6, 2021 Peer-review started: January 6, 2021 First decision: February 11, 2021 Revised: February 19, 2021 Accepted: March 11, 2021 Article in press: March 11, 2021 Published online: April 16, 2021 Processing time: 95 Days and 23.3 Hours
Core Tip
Core Tip: Limited society guidelines currently exist to aid endoscopists in the selection of the most appropriate sedation method. Rather, it is at the discretion of the endoscopist on a case-by-case basis, with many decisions made based on gut feeling and previous personal experience. With the growing focus on patient satisfaction as a metric for reimbursement and an increased focus on healthcare cost containment initiatives, identifying which patients can safely and effectively undergo endoscopy without anesthesia-administered sedation is becoming exceedingly important. Existing studies on this topic to date have been small scale, single-center data with inconsistent findings. Robust data to drive practice patterns have been lacking. As such, we have capitalized upon nationwide data found in the Clinical Outcomes Research Initiative National Endoscopic Database to clarify these discrepancies and to identify patient and procedure characteristics that may predict better patient tolerance to endoscopy with moderate sedation.
