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World J Gastrointest Endosc. Dec 16, 2021; 13(12): 593-606
Published online Dec 16, 2021. doi: 10.4253/wjge.v13.i12.593
Composite intestinal adenoma-microcarcinoid: An update and literature review
Zhi-Yan Fu, Michel Kmeid, Mahmoud Aldyab, Stephen M Lagana, Hwajeong Lee
Zhi-Yan Fu, Michel Kmeid, Mahmoud Aldyab, Hwajeong Lee, Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY 12208, United States
Stephen M Lagana, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, United States
Author contributions: Fu ZY carried out the study including review of the literature, and drafted the manuscript, gave final approval of the version to be published; Kmeid M, Aldyab M and Lagana SM contributed to the editing and critical review of the manuscript, as well as final approval of the version to be published; Lee H provided cases for microscopic images, edited and critically reviewed the manuscript, and approved the final version to be published; all authors are agreeable to be accountable for all aspects of the work.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hwajeong Lee, MD, Associate Professor, Pathology and Laboratory Medicine, Albany Medical Center, 43 New Scotland Ave, Albany, NY 12208, United States.leeh5@amc.edu
Received: March 12, 2021
Peer-review started: March 12, 2021
First decision: October 17, 2021
Revised: October 19, 2021
Accepted: November 26, 2021
Article in press: November 26, 2021
Published online: December 16, 2021
Processing time: 276 Days and 8.4 Hours
Core Tip

Core Tip: Composite intestinal adenoma-microcarcinoid (CIAM) is a rare intestinal lesion consisting of adenoma and well differentiated microcarcinoid components. While it is a form of mixed neoplasm with both neuroendocrine and non-neuroendocrine elements, CIAM is currently not recognized as a distinct subtype of mixed neoplasm by WHO. It is found incidentally during the pathologic examination of adenomatous polyps. Altered Wnt/β-catenin pathway appears to play a role in its pathogenesis. Other benign and malignant lesions need to be distinguished from CIAM given differing therapeutic implications. CIAM is an indolent disease with a favorable outcome.