Retrospective Cohort Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Aug 16, 2020; 12(8): 212-219
Published online Aug 16, 2020. doi: 10.4253/wjge.v12.i8.212
Improved diagnostic yield of endoscopic ultrasound-fine needle biopsy with histology specimen processing
Lawrence Ku, Mohammad A Shahshahan, Linda A Hou, Viktor E Eysselein, Sofiya Reicher
Lawrence Ku, Mohammad A Shahshahan, Linda A Hou, Viktor E Eysselein, Sofiya Reicher, Department of Medicine, Division of Gastroenterology and Hepatology, Harbor-UCLA Medical Center, Torrance, CA 90509, United States
Author contributions: Ku L and Reicher S contributed to study design, data collection, data analysis, manuscript drafting, manuscript revision, and final approval of the manuscript; Shahshahan MA contributed to data collection, data analysis, manuscript drafting, and manuscript revision; Hou LA and Eysselein VE contributed to data collection, manuscript drafting, and manuscript revision.
Supported by the National Center for Advancing Translational Sciences through University of California, Los Angeles Clinical and Translational Science Institute Grant, No. UL1TR001881-01.
Institutional review board statement: The study was approved by the Institutional Review Board, No. 31297-01.
Informed consent statement: Not applicable to this retrospective cohort study.
Conflict-of-interest statement: Sofiya Reicher is a consultant for Boston Scientific; all other authors have no conflicts of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at sreicher@dhs.lacounty.gov. Consent was not obtained, but the presented data are anonymized and risk of identification is low.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE Statement checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Sofiya Reicher, MD, Associate Professor, Attending Doctor, Director, Department of Medicine, Division of Gastroenterology and Hepatology, Harbor-UCLA Medical Center, 21840 South Normandie Ave, Ste 850, Torrance, CA 90509, United States. sreicher@dhs.lacounty.gov
Received: March 26, 2020
Peer-review started: March 26, 2020
First decision: April 22, 2020
Revised: June 4, 2020
Accepted: July 18, 2020
Article in press: July 18, 2020
Published online: August 16, 2020
Processing time: 139 Days and 9.3 Hours
Core Tip

Core tip: Endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) is rapidly gaining in popularity. However, the optimal method for EUS-FNB specimen processing is not well defined, with recent studies on fine needle biopsy (FNB) varying widely in the use of histology vs cytology for FNB sample evaluation. Our data suggest that processing FNB specimens in formalin for histology, followed by evaluation by an anatomic pathologist, could contribute to overall improved diagnostic yield of EUS-FNB. An additional benefit is the decreased need for on-site cytopathology.