Tabibian JH, Perrault JF, Murray JA, Papadakis KA, Enders FT, Gostout CJ. Narrow band imaging evaluation of duodenal villi in patients with and without celiac disease: A prospective study. World J Gastrointest Endosc 2019; 11(2): 145-154 [PMID: 30788033 DOI: 10.4253/wjge.v11.i2.145]
Corresponding Author of This Article
James H Tabibian, MD, PhD, Associate Professor of Medicine, Director of Endoscopy, Division of Gastroenterology, Olive View-UCLA Medical Center, 14445 Olive View Dr., 2B-182, Sylmar, CA 91342, United States. jtabibian@dhs.lacounty.gov
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
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Tabibian JH, Perrault JF, Murray JA, Papadakis KA, Enders FT, Gostout CJ. Narrow band imaging evaluation of duodenal villi in patients with and without celiac disease: A prospective study. World J Gastrointest Endosc 2019; 11(2): 145-154 [PMID: 30788033 DOI: 10.4253/wjge.v11.i2.145]
World J Gastrointest Endosc. Feb 16, 2019; 11(2): 145-154 Published online Feb 16, 2019. doi: 10.4253/wjge.v11.i2.145
Narrow band imaging evaluation of duodenal villi in patients with and without celiac disease: A prospective study
James H Tabibian, Jean F Perrault, Joseph A Murray, Konstantinos A Papadakis, Felicity T Enders, Christopher J Gostout
James H Tabibian, Jean F Perrault, Joseph A Murray, Konstantinos A Papadakis, Christopher J Gostout, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States
James H Tabibian, Division of Gastroenterology, Olive View-UCLA Medical Center, Sylmar, CA 91342, United States
Felicity T Enders, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN 55905, United States
Author contributions: Tabibian JH, Perrault JF, Enders FT, and Gostout CJ designed the study; Tabibian JH, Perrault JF, Murray JA, and Papadakis KA acquired images; Tabibian JH, Perrault JF, Murray JA, Papadakis KA and Gostout CJ reviewed images; Tabibian JH drafted the manuscript; Enders FT provided statistical support; Perrault JF and Gostout CJ provided supervision; all authors provided critical input on and approved of the manuscript.
Supported bythe National Institutes of Health, No. T32DK007198 in part during the study period.
Institutional review board statement: Exempt status was obtained from the Mayo Clinic IRB.
Conflict-of-interest statement: No conflicts of interest.
Corresponding author: James H Tabibian, MD, PhD, Associate Professor of Medicine, Director of Endoscopy, Division of Gastroenterology, Olive View-UCLA Medical Center, 14445 Olive View Dr., 2B-182, Sylmar, CA 91342, United States. jtabibian@dhs.lacounty.gov
Telephone: +1-747-2103205 Fax: +1-747-2104573
Received: November 5, 2018 Peer-review started: November 5, 2018 First decision: November 28, 2018 Revised: January 9, 2019 Accepted: January 26, 2019 Article in press: January 26, 2019 Published online: February 16, 2019 Processing time: 106 Days and 13 Hours
Core Tip
Core tip: Duodenal mucosal biopsies are frequently obtained during upper endoscopy to assess villous architecture but are largely negative (i.e., histopathologically normal); thus, a method to better evaluate the duodenal mucosa and avoid unnecessary biopsies is needed. Narrow band imaging (NBI) permits superior inspection of mucosal surfaces via filter separation of conventional white light into only green and blue components. Based on the findings of this prospective study, NBI appears to have excellent diagnostic performance in evaluating duodenal villous morphology and can facilitate targeting of biopsies; its high negative predictive value renders it particularly useful in avoiding biopsies that are likely to reveal histopathologically normal mucosa.
