Takagi T, Sugimoto M, Suzuki R, Konno N, Asama H, Sato Y, Irie H, Watanabe K, Nakamura J, Kikuchi H, Takasumi M, Hashimoto M, Hikichi T, Ohira H. Appropriate number of biliary biopsies and endoscopic retrograde cholangiopancreatography sessions for diagnosing biliary tract cancer. World J Gastrointest Endosc 2019; 11(3): 231-238 [PMID: 30918588 DOI: 10.4253/wjge.v11.i3.231]
Corresponding Author of This Article
Mitsuru Sugimoto, MD, PhD, Assistant Professor, Department of Gastroenterology, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima Prefecture, Fukushima 960-1247, Japan. kita335@fmu.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mar 16, 2019 (publication date) through Feb 15, 2026
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Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Endoscopy
ISSN
1948-5190
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Takagi T, Sugimoto M, Suzuki R, Konno N, Asama H, Sato Y, Irie H, Watanabe K, Nakamura J, Kikuchi H, Takasumi M, Hashimoto M, Hikichi T, Ohira H. Appropriate number of biliary biopsies and endoscopic retrograde cholangiopancreatography sessions for diagnosing biliary tract cancer. World J Gastrointest Endosc 2019; 11(3): 231-238 [PMID: 30918588 DOI: 10.4253/wjge.v11.i3.231]
World J Gastrointest Endosc. Mar 16, 2019; 11(3): 231-238 Published online Mar 16, 2019. doi: 10.4253/wjge.v11.i3.231
Appropriate number of biliary biopsies and endoscopic retrograde cholangiopancreatography sessions for diagnosing biliary tract cancer
Tadayuki Takagi, Mitsuru Sugimoto, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Mika Takasumi, Minami Hashimoto, Takuto Hikichi, Hiromasa Ohira
Tadayuki Takagi, Mitsuru Sugimoto, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Mika Takasumi, Minami Hashimoto, Hiromasa Ohira, Department of Gastroenterology, Fukushima Medical University, School of Medicine, Fukushima 960-1247, Japan
Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Minami Hashimoto, Department of Endoscopy, Fukushima Medical University Hospital, Fukushima 960-1247, Japan
Author contributions: Takagi T and Sugimoto M designed and performed the study; Takagi T, Sugimoto M and Ohira H analyzed the data and wrote the paper; Suzuki R, Konno N, Asama H, Watanabe K, Nakamura J, Kikuchi H, Takasumi M, Sato Y, Hashimoto M and Hikichi T provided clinical advice; and Hikichi T and Ohira H supervised the study.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Fukushima Medical University.
Informed consent statement: Patients were not required to give informed consent for participation in the study because the analysis used anonymous clinical data obtained after each patient provided written consent agreeing to treatment. For full disclosure, the details of the study are published on the home page of Fukushima Medical University.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Corresponding author: Mitsuru Sugimoto, MD, PhD, Assistant Professor, Department of Gastroenterology, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima Prefecture, Fukushima 960-1247, Japan. kita335@fmu.ac.jp
Telephone: +81-24-5471202 Fax: +81-24-5472055
Received: January 26, 2019 Peer-review started: January 27, 2019 First decision: February 20, 2019 Revised: February 28, 2019 Accepted: March 11, 2019 Article in press: March 11, 2019 Published online: March 16, 2019 Processing time: 49 Days and 16.6 Hours
ARTICLE HIGHLIGHTS
Research background
Biliary ductal cancer (BDC) is a lethal disease; however, the histological diagnosis of BDC is difficult.
Research motivation
Histological diagnosis of BDC is achieved by endoscopic biliary biopsy except for surgery. However, the appropriate method (i.e., the number of times, the number of ERCP sessions) for biliary biopsy is unknown.
Research objectives
This study aims to clarify the appropriate method of endoscopic biliary biopsy.
Research methods
The subjects of this study were patients who were histologically diagnosed with BDC. The patients who could be diagnosed by biliary biopsy were determined as the positive group (P group), and the patients who could not be diagnosed by biliary biopsy were determined as the negative group (N group). The methods for ERCP procedures were compared between the P group and the N group.
Research results
Multiple ERCP sessions did not contribute to the improvement of the diagnosability of biliary biopsy.
Research conclusions
If biliary cancer is not pathologically diagnosed after the first session of ERCP, other methods should be employed.
Research perspectives
From the results of this study, several methods will be developed and tested for diagnosing BDC.
