Case Report
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World J Gastrointest Endosc. May 16, 2013; 5(5): 261-264
Published online May 16, 2013. doi: 10.4253/wjge.v5.i5.261
Serrated adenoma of the stomach: Case report and literature review
Carlos A Rubio, Jan Björk
Carlos A Rubio, Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
Jan Björk, Department of Gastroenterology, Karolinska University Hospital, 17176 Stockholm, Sweden
Author contributions: Rubio CA performed the pathological examination, designed and wrote the paper; Björk J was the attending doctor for the patient, provided the clinical data and the endoscopic illustration; Both authors critically revised the draft and approved the final version to be published.
Correspondence to: Dr. Carlos A Rubio, Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Hälsovägen, Flemingsberg, 17176 Stockholm, Sweden. carlos.rubio@ki.se
Telephone: +46-8-51774527 Fax: +46-8-51774524
Received: February 18, 2013
Revised: April 9, 2013
Accepted: April 17, 2013
Published online: May 16, 2013
Processing time: 84 Days and 16.4 Hours
Abstract

Gastric serrated adenomas are histologically characterized by protruding glands with lateral saw tooth-like indentations lined with stratified dysplastic cells containing abundant eosinophilic cytoplasm. Since the first case of gastric serrated adenoma found in 2001, 18 additional cases have been reported. Gastric serrated adenomas have a particular proclivity to progress to invasive carcinoma; 75% or 15 of the 20 cases now in record - including the present one - exhibited invasive carcinoma. The 20th case of gastric serrated adenoma reported here differs from the preceding ones in as much as it evolved in a patient with Lynch syndrome, implying that this adenoma phenotype may develop not only sporadically but also in patients with hereditary traits.

Keywords: Gastric; Serrated; Neoplasia; Lynch syndrome

Core tip: Gastric serrated adenomas have a particular proclivity to progress to invasive carcinoma; 75% or 15% of the 20 cases that are now in record - including the present one - exhibited invasive carcinoma.