Samanta A, Singh V, Chakraborty B, Ray G. Eosinophilic esophagitis in children: Clinical perspectives and evolving therapeutic strategies. World J Gastrointest Endosc 2026; 18(2): 114779 [DOI: 10.4253/wjge.v18.i2.114779]
Corresponding Author of This Article
Arghya Samanta, Assistant Professor, Department of Pediatric Gastroenterology, Institute of Post Graduate Medical Education and Research, Raebareli Road, Lucknow, Kolkata 700020, West Bengal, India. arghyasamanta2905@gmail.com
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Gastroenterology & Hepatology
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Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feb 16, 2026 (publication date) through Feb 4, 2026
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World Journal of Gastrointestinal Endoscopy
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1948-5190
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Samanta A, Singh V, Chakraborty B, Ray G. Eosinophilic esophagitis in children: Clinical perspectives and evolving therapeutic strategies. World J Gastrointest Endosc 2026; 18(2): 114779 [DOI: 10.4253/wjge.v18.i2.114779]
World J Gastrointest Endosc. Feb 16, 2026; 18(2): 114779 Published online Feb 16, 2026. doi: 10.4253/wjge.v18.i2.114779
Eosinophilic esophagitis in children: Clinical perspectives and evolving therapeutic strategies
Arghya Samanta, Vishrut Singh, Bipresh Chakraborty, Gautam Ray
Arghya Samanta, Gautam Ray, Department of Pediatric Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata 700020, West Bengal, India
Vishrut Singh, Department of Pediatrics, Aster Jubilee Medical Complex, Bur Dubai 8703, United Arab Emirates
Bipresh Chakraborty, Department of Internal Medicine, Institute of Post Graduate Medical Education and Research, Kolkata 700020, West Bengal, India
Author contributions: Samanta A designed the overall concept and outline of the manuscript and did the literature review and critical revision of the manuscript; Singh V, Chakraborty B, and Ray G did the literature review, wrote the initial manuscript draft, and contributed to the editing of the manuscript; All authors read and approved the final manuscript.
Conflict-of-interest statement: All authors declare no conflicts of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arghya Samanta, Assistant Professor, Department of Pediatric Gastroenterology, Institute of Post Graduate Medical Education and Research, Raebareli Road, Lucknow, Kolkata 700020, West Bengal, India. arghyasamanta2905@gmail.com
Received: September 28, 2025 Revised: October 31, 2025 Accepted: December 10, 2025 Published online: February 16, 2026 Processing time: 128 Days and 17.2 Hours
Abstract
Eosinophilic esophagitis (EoE) is a chronic, antigen-mediated inflammatory condition of the esophagus, characterized by signs of esophageal dysfunction and characteristic endoscopic and histological features. Currently, EoE has developed from a rare disease entity to a prevalent condition with a rising incidence and prevalence in children. Over the past few decades, a deeper understanding of the underlying pathophysiologic mechanisms of EoE has led to better diagnostic and therapeutic strategies. Pediatric patients with EoE face a diagnostic dilemma due to a wide spectrum in symptomatology as well as limited pharmacological armamentarium. Emerging literature is showing promise, especially with dupilumab, a newer biologic with disease modifying potential. In this review we discussed new diagnostic and treatment strategies and future directions of monitoring EoE in children.
Core Tip: Eosinophilic esophagitis is being increasingly diagnosed in children. However, clear guidelines to diagnose and manage these cases are limited. We presented a concise update of the guidelines to simplify management protocols, thus improving patient outcomes.
